Overview

The two broad categories of mammalian stem cells exist: embryonic stem cells, derived from blastocysts, and adult stem cells, which are found in adult tissues. In a developing embryo, stem cells are able to differentiate into all of the specialised embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialised cells. As stem cells can be readily grown and transformed into specialised tissues such as muscles or nerves through cell culture, their use in medical therapies has been proposed. In particular, embryonic cell lines, autologous embryonic stem cells generated therapeutic cloning, and highly plastic adult stem cells from the umbilical cord blood or bone marrow are touted as promising candidates. Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents leading research from around the world in this field which is of interest to so many and presents so many hopes.

Full Product Details

Author:   Dr Prasad S Koka
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   1.114kg
ISBN:  

9781604565997

ISBN 10:   1604565993
Pages:   435
Publication Date:   13 August 2008
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface; Foreword: Stem Cells; Megakaryocytopoiesis: From Marrow Stem Cells to Circulating Platelets; A Novel Serum-Free Culture System for the Analysis of Human Hematopoietic Progenitor Cells; Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures; The Cardiogenic Potential of Mouse and Human Embryonic Stem Cells: Cognitive Research to Envision the Therapeutic Use of the Cells Hemopoietic Stem Cells and Autoimmunity: Impaired Mechanisms of Thymic Selection or Genetic Predisposition?; Control of Tissue Regeneration through Oxygen Concentrations; Control of Thymocyte Proliferation and Thymus Organ Size by CDK Inhibitors; Human Embryonic Stem Cell-Derived Cardiomyocytes: Therapeutic Potentials and Limitations; Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors; Diminished Gene Expression in Human Mesenchymal Stem Cells by Mutation of Focal Adhesion Kinase Signalling; Stem Cells as Therapy for Cardiovascular Disease: Lost in Translation?; Human Chimerism and Tetragametism: Relevance of Embryonic or/and Hematopoietic Stem Cells; Mathematical Modeling of T Cell Differentiation from Hemopoietic Stem Cell Progenitors; The Importance of Large Animal Models in Stem Cell Research; Hypoxia Expands Primitive Hematopoietic Progenitor Cells from Mouse Bone Marrow During In-Vitro Culture and Preserves The Colony-Forming Ability; A Versatile Method for Differentiation of Multiple Neuronal Subtypes from Mouse Embryonic Stem Cells; Signaling Pathways Involved in the Maintenance of Human Embryonic Stem Cells; Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host That Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients; The Effects of EX Vivo Expansion on the Differentiation of Umbilical Cord Blood-Derived CD34+ Cells; Index.

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