Overview

This text deals with two different developments with haematopoietic stem cells. The first is their retrieval from cord blood as an alternative to bone marrow. Since this approach was first suggested in 1990, there has been worldwide activity to establish cord blood banks, and more than 10,000 samples have been entered and 1000 transplanted in one centre alone. The second application of haematopoietic stem cells is therapy in utero, for example of inborn errors of metabolism. The first successful treatment of effective severe combined immunodeficiency in utero have been reported, though many problems remain to be solved.

Full Product Details

Author:   Wolfgang Holzgreve ,  Monika Lessl
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 33
Weight:   0.460kg
ISBN:  

9783540677017

ISBN 10:   3540677011
Pages:   248
Publication Date:   06 November 2000
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Plasticity of stem cells; lentiviral vectors for the genetic modification of haematopoietic stem cells; origin and developmental plasticity of haematopoietic stem cells; the New York Blood Center's placental/umbilical cord blood programme; experience with a new source of haematopoietic stem cells for transplantation; chances and limits of cord blood transplantation; legal and ethical issues involved in cord blood transplantations and banking; foetal somatic gene therapy - a preventive approach to the treatment of genetic disease, the case for; prenatal transplantation of haematopoietic stem cells - overview; foetal haematopoietic stem cells - in vitro expansion and transduction using lentiviral vectors; tolerance induction post in utero stem cell transplantation; foetal haematopoiesis during first and second trimester of pregnancy - relevance for in utero stem cell transplantation; tolerance induction following in utero stem cell transplantation; in utero stem cell transplantations in humans.

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