Overview

Tissue is frequently damaged or lost in injury and disease. There has been an increasing interest in stem cell applications and tissue engineering approaches in surgical practice to deal with damaged or lost tissue. Tissue engineering is an exciting strategy being explored to deal with damaged or lost tissue. It is the science of generating tissue using molecular and cellular techniques, combined with material engineering principles, to replace tissue. This could be in the form of cells with or without matrices. Although there have been developments in almost all surgical disciplines, the greatest advances are being made in orthopaedics, especially in cartilage repair. This is due to many factors including the familiarity with bone marrow derived mesenchymal stem cells and cartilage being a relatively simpler tissue to engineer. Unfortunately significant hurdles remain to be overcome in many areas before tissue engineering becomes more routinely used in clinical practice.

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9781608768646

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Wasim Khan is a Honorary Clinical Lecturer at University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore. Following his medical degree, he undertook research in stem cell biology and tissue engineering before completing his higher surgical training in Trauma and Orthopaedics. He has also completed a higher degree in Orthopaedic Engineering. He has held fellowships with the Medical Research Council, Royal College of Surgeons, AO Foundation, British Orthopaedic Association and the British Orthopaedic Research Society. He has published extensively in the Journal of Perioperative Practice and his publications in the journal form the basis of this book. He has authored over 500 chapters, editorials, papers, abstracts and letters.

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