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Author:   Joaquim M.S. Cabral (Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisbon, Portugal) ,  Claudia Lobato da Silva (Department of Bioengineering, Instituto Superior Técnico, Lisboa, Portugal) ,  Lucas G. Chase (Cellular Dynamics International, Inc., Madison, WI, USA) ,  M. Margardia Diogo (Stem Cell Bioengineering Laboratory, Instituto Superior Técnico (IST), Technical University of Lisbon, Portugal)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Dimensions:   Width: 19.10cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.960kg
ISBN:  

9780444632654

ISBN 10:   0444632654
Pages:   340
Publication Date:   25 July 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Genetic Engineering in Stem Cell Manufacturing 2. Biomechanics in Stem Cell Manufacturing 3. Bioreactor Engineering Fundamentals for Stem Cell Manufacturing 4. Microcarrier Culture Systems for Stem Cell Manufacturing 5. Novel Single-Use Bioreactors for Scale up of Anchorage-Dependent Cell Manufacturing for Cell Therapies 6. Bioreactors and Downstream Processing for Stem Cell Manufacturing 7. Cell production system based on flexible modular platform 8. Microfluidic Devices for the Culture of Stem Cells 9. Enrichment and Separation Technologies for Stem Cell-Based Therapies 10. Expansion and Characterization Considerations for the Manufacturing of Stem Cells 11. Storage and Delivery of Stem Cells for Cellular Therapies 12. Business Models for Manufacture of Cellular Therapies 13. Stem cells for the regeneration of chronic wounds: a translational perspective

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Author Information

Dr Joaquim M. S. Cabral is Professor of Biological Engineering, in the Department of Bioengineering at Instituto Superior Técnico (IST), Technical University of Lisbon, Portugal. He was the founder and current Head of Department of Bioengineering, and the Director of the Institute for Biotechnology and Bioengineering, a Research Laboratory Associated to the Ministry of Science, Technology and Higher Education in Portugal. His research aims at contributing to biochemical engineering science through novel developments in Bioprocess Engineering and Stem Cell Bioengineering. Dr. Cláudia Lobato da Silva, born in Lisboa, Portugal, 1978, received a Diploma in Chemical Engineering (Biotechnology), Instituto Superior Técnico (IST), Technical University of Lisboa (Universidade Técnica de Lisboa, UTL), Portugal, in 2001 and got a Ph.D. in Biotechnology in 2006 at IST-UTL in collaboration with the University of Nevada, Reno, USA.Dr. Cláudia Lobato da Silva is Assistant Professor at the Department of Bioengineering, IST-UTL, Lisboa, Portugal, and is co-author of 32 scientific articles published in international peer-reviewed journals and 4 book chapters. Her research interests include expansion of human stem cells, namely hematopoietic and mesenchymal stem cells, cellular therapies with human adult stem cells, isolation and purification of stem cells, and bioreactors for stem cell culture. At IST-UTL, Dr. Cláudia Lobato da Silva is the faculty responsible for the courses “Cell and Tissue Engineering” (since 2008/2009) and “Stem Cell Bioengineering” (since 2010/2011), whose attendees include MSc students in Biological Engineering and Biomedical Engineering. Recently, Dr. Cláudia Lobato da Silva was appointed as Associate Editor of BMC Biotechnology. Dr. Lucas Chase has extensive research experience in both adult and pluripotent stem cell biology. After obtaining a Ph.D. from the Molecular, Cellular, Developmental Biology and Genetics program at the University of Minnesota, Dr. Chase joined the Stem Cells unit at Invitrogen Corporation (now Life Technologies) in 2007, working on the development of cGMP culture media, advanced cellular models and drug discovery assays. In 2010, Dr. Chase joined Cellular Dynamics International, the world's largest producer of fully functional human cells derived from induced pluripotent stem (iPS) cells, to support development of novel cell-based models for drug discovery and basic life science applications. In addition to co-authoring numerous articles and book chapters, Dr. Chase has also co-edited two books, Mesenchymal stem Cell Assays and Applications and Mesenchymal Stem Cell Therapy. Dr Maria Margarida Diogo received her PhD degree in Biotechnology from Instituto Superior Técnico (IST) from January 2000 to April 2004. Her thesis was dedicated to the development of Bioprocesses for Production and Purification of Plasmid DNA for Gene Therapy and DNA vaccines. As a result of this work, a United States Patent was published in 2007. From April 2004 to March 2008 she received a post-doctoral fellowship to work in the field of Stem Cell Bioengineering and she is presently a Research Scientist at the Stem Cell Bioengineering Laboratory at Instituto Superior Técnico (IST).

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