Overview

A practical guide to stem cell-based regenerative techniques in dogs Stem Cell-Based Regenerative Medicine in Canine Practice delivers an essential reference for the use of stem cells in canine practice. Intuitively organized by organ and body systems, the book is easy-to-follow, and addresses many common conditions encountered when dealing with dogs in veterinary practice, including those affecting the central nervous system, muscular system, and vascular system. The book is grounded in evidence-based research and readers are provided with guidance on the potential challenges and problems that may arise when considering and using stem cell therapeutics. It also explains the techniques for stem cell extraction and how to use stem cell regenerative medicine for the best results. Readers will also find: An introduction to the treatment of various clinical conditions like corneal ulcers and keratoconjunctivitis Comprehensive explorations of the treatment of osteoarthritis, bone gap defects, tendon/ligament injuries, muscle affections, peripheral nerves, periodontitis, esophageal ulcers, inflammatory bowel disease, liver, diabetes, and skin wounds Practical discussions of canine mesenchymal stem cell sources, properties, and regulations for clinical use An overview of comparative analysis between various stem cells for therapeutics Complimentary access to a website containing reference videos and clinical guidance Written for veterinarians in general practice, Stem Cell-Based Regenerative Medicine in Canine Practice will also benefit veterinary students and researchers.

Full Product Details

Author:   Mudasir Bashir Gugjoo (Sher-e-Kashmir University of Agricultural Sciences & Technology of Kashmir)
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 16.00cm , Height: 3.10cm , Length: 23.10cm
Weight:   1.043kg
ISBN:  

9781394253258

ISBN 10:   1394253257
Pages:   592
Publication Date:   10 July 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

About the Author xiii Foreword xv Preface xvii Abbreviations xix About the Companion Website xxxiii 1 Canine Mesenchymal Stem Cells Sources, Properties, and Regulations for Clinical Use 1 1.1 Introduction 1 1.2 Understanding the Stem Cell 3 1.3 Sources of Dog MSCs for Proliferation 9 1.4 Why Do We Need to Culture Mesenchymal Stem Cells? 10 1.5 Why to Characterize MSCs? 11 1.6 Factors Affecting MSCs Therapeutic Outcome 12 1.7 Stem Cell Regulations in Research and Therapeutics 13 2 Osteoarthritis 27 2.1 Introduction 27 2.2 Predisposing Factors 28 2.3 OA Pathogenesis 30 2.4 MSCs and Their Potential Therapeutic Role in OA 37 2.5 In Vivo MSCs Studies 42 3 MSCs in Canine Bone Tissue Engineering 97 3.1 Introduction 97 3.2 Mesenchymal Stem Cells and Bone Regeneration 99 3.3 In Vivo Studies 107 4 Muscle, Tendon, and Ligament Affections 149 4.1 Introduction 149 4.2 Why Mesenchymal Stem Cells and Not Tendon Stem/Progenitor Cells (TSPCs)? 152 4.3 In Vivo Studies 160 4.4 Muscle Studies 175 5 Peripheral Nerve Affections 197 5.1 Introduction 197 5.2 Peripheral Nerve Injury 199 5.3 Why MSCs and Not Schwann Cells for Nerve Regeneration 206 5.4 In Vivo Peripheral Nerve Injury Studies 207 6 Central Nervous System Affections 225 6.1 Introduction 225 6.2 CNS Intrinsic Regeneration Potential 226 6.3 Exogenous Stem Cell Therapy 227 7 Myocardial and Valvular Diseases 287 7.1 Introduction 287 7.2 Why MSCs in Cardiac Diseases? 288 7.3 In Vivo MSCs Therapeutic Studies in Dogs 296 8 Oral and Esophageal Affections 341 8.1 Introduction 341 8.2 Oral Mucosal Ulcers 344 8.3 Periodontal Disease 347 8.4 Maxillary Alveolar Bone Cleft Model 359 8.5 Peri-implant Defect Models 360 8.6 Esophagus 362 9 Inflammatory Bowel Disease and Anal Furunculosis 377 9.1 Introduction 377 9.2 Why Mesenchymal Stem Cells 382 9.3 In Vivo Studies 384 10 Liver Affections 397 10.1 Introduction 397 10.2 Regenerative Medicine in Canine Hepatology 398 10.3 In Vivo Liver Regenerative Studies 404 10.4 Hepatocutaneous Syndrome 409 11 Lung Affections 419 11.1 Introduction 419 11.2 MSCs Potential Therapeutic Effects 421 11.3 In Vivo Studies 423 12 Renal Insufficiency and Urinary Bladder Affections 435 12.1 Introduction 435 12.2 In Vitro Renal Studies 437 12.3 In Vivo Renal Studies 441 12.4 Urinary Bladder 450 13 Skin Wounds and Atopic Dermatitis 461 13.1 Introduction 461 13.2 In Vivo Skin Wound-Healing Studies Using MSCs 462 13.3 Atopic Dermatitis (AD) 472 14 Diabetes 487 14.1 Introduction 487 14.2 In Vitro Studies 490 14.3 In Vivo Studies 499 15 Corneal Ulcers and Keratoconjunctivitis Sicca 517 15.1 Introduction 517 15.2 Mesenchymal Stem Cells (MSCs) Versus Corneal/Limbal Stem Cells 518 15.3 Corneal Affections 521 15.4 Keratoconjunctivitis Sicca (KCS) 527 References 532 Index 543

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Author Information

The Author Mudasir Bashir Gugjoo, PhD, is a Senior Assistant Professor at the Division of Veterinary Clinical Complex, Faculty of Veterinary Sciences & Animal Husbandry of the Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, India.

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