Overview

Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.

Full Product Details

Author:   Chandrashekhar Gandhi (Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA) ,  Massimo Pinzani (UCL Institute for Liver and Digestive Health, University College London, Royal Free Hospital Campus U3, UK)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.790kg
ISBN:  

9780128001349

ISBN 10:   0128001348
Pages:   336
Publication Date:   14 April 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1. History and Early Work Chapter 2. Stellate Cell Culture Models Chapter 3. Hepatic Fibrosis: A Global Clinical Problem Chapter 4. Stellate Cells and Hepatic Fibrosis Chapter 5. Cytokin Production and Signaling in Stellate Cells Chapter 6. Stellate Cells, Portal Myofibroblasts and Epithelial-Mesenchymal Transition Chapter 7. Matrix Melalloproteinases and their Inhibitors Chapter 8. Matrix Melalloproteinases and their Inhibitors Chapter 9. Stellate Cells and Liver Cancer Chapter 10. Morphogens and hepatic stellate cell fate regulation Chapter 11. Stellate Cells in alcoholic Steatohepatitis Chapter 12. Stellate Cells as target for Reversal of Fibrosis/Cirrhosis Chapter 13. Interactions of Stellate Cells with other Nonparenchymal Cells Chapter 14. Stellate Cells in Regulation of Hepatocyte Survival and Functions Chapter 15. Stellate Cells in hepatic Immunobiology Chapter 16. Stellate Cell Depletion Models Chapter 17. Stellate Cells in Nonhepatic Organs

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Author Information

Dr. Chandrashekhar Gandhi is a professor within the department of Surgery at the University of Cincinnati. His laboratory focuses on the mechanisms of intercellular communications that regulate the structure and function of the liver in physiology and pathology. Present research elucidates specific molecular and biochemical mechanisms underlying effects of stellate cells. Dr. Gandhi is a member of the American Association for Advancement of Science, The New York Academy of Sciences, American Society for Biochemistry and Molecular Biology, International Liver Transplantation Society, American Association for the Study of Liver Diseases, and the American Society for Investigative Pathology. He has contributed over 70 published research articles and owns the patent for “Diagnostic and Therapeutic Uses of Augmenter of Liver Regeneration (ALR) in Inflammatory Conditions” (PCT/US2008/075440).

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