Overview

Spatial variable genes (SVGs) in cancer refer to genes that exhibit different expression levels or patterns across different regions or cells within a tumor. Cancer-associated fibroblasts (CAFs) are a crucial component of the tumor microenvironment (TME), playing a fundamental role in tumor progression, metastasis, and therapy response. Identifying and characterizing SVGs can reveal novel targets for cancer treatment. Combining spatial transcriptomics with other omics data can provide a more comprehensive picture of tumor biology. Spatially Variable Genes in Cancer: Development, Progression, and Treatment Response illuminates the heterogeneity within tumors, challenging the traditional one-size-fits-all approach. The chapters examine how SVGs influence tumor biology and pave the way for novel diagnostic and therapeutic approaches. Covering topics such as bioengineering, gene expression, and tumor initiation, this book is an excellent resource for academicians, researchers, students, oncologists, medical professionals, medical administrators, scientists, and more.

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Ramya Raghavan is Assistant Professor at Sri Sathya Sai University for Human Excellence, India. Dr Raghavan’s research interests include Genetics, Biostatistics, Biophotons, Epigenetic factors Intellectual disability, Assistive Technologies. Her recent editorial work on a book dedicated to advancing cancer treatment through spatial omics approaches underscores her commitment to innovation. As an experienced editor specializing in medical and scientific publications, Dr. Raghavan possesses a unique ability to bridge complex scientific concepts with broader societal impact. Her expertise extends to the critical intersection of the exposome and Social Determinants of Health (SDOH). Dr. Raghavan's work underscores how a holistic understanding of environmental exposures, from the molecular level to population-wide influences. Currently working on various early developmental programming projects, aligning with the Developmental Origins of Health and Disease (DOHaD) paradigm and also addressing health disparities and equitable approach to disease prevention.

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