Overview

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity-associated findings collectively define the Spaceflight Associated Neuro-ocular Syndrome (SANS). In this book, the editors compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. The book describes the possible mechanisms and potential etiologies for SANS, and provides an update and review on the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). The ocular imaging findings (e.g., retinal nerve fiber layer, optic disc, and choroidal changes on optical coherence tomography) of SANS is also described, including the intraorbital and intracranial findings on orbital ultrasound and magnetic resonance imaging. The knowledge gaps for in-flight and terrestrial human research including potential countermeasures for future stud is also explored, including reports on the in-flight and terrestrial human and animal research being investigated by NASA and its partners to study SANS both prospectively and longitudinally and in preparation for future long duration manned missions to space including the moon, the asteroid belt, or Mars. We think this is a unique topic and hope that NASA and its research partners continue to study SANS in preparation for future longer duration manned space missions.

Full Product Details

Publisher:   Elsevier Science & Technology
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780323915243

ISBN 10:   0323915248
Pages:   240
Publication Date:   01 August 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. An introduction to space medicine and the physiological effects of spaceflight on the human body Joshua Ong and Andrew G. Lee 2. Neuro-ocular findings and mechanisms in Spaceflight Associated Neuro-Ocular Syndrome Thomas H. Mader and C. Robert Gibson 3. Optical coherence tomography and Spaceflight Associated Neuro-Ocular Syndrome Nimesh B. Patel, Thomas H. Mader and C. Robert Gibson 4. Clinical neuroimaging of Spaceflight Associated Neuro-Ocular Syndrome Luis Nunez-Rubiano, Azin Aein and Roy Riascos 5. Genetics, vitamins, and Spaceflight Associated Neuro-Ocular Syndrome S.R. Zwart and S.M. Smith 6. Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome Peter Wostyn and Maiken Nedergaard 7. Mechanical alterations of the brain and optic chiasm in Spaceflight Associated Neuro-Ocular Syndrome A. Taniguchi-Shinojima 8. Intraocular pressure and Spaceflight Associated Neuro-Ocular Syndrome Shehzad Batliwala, Brian M. Shafer and John P. Berdahl 9. Intraocular and intracranial pressure relationships for Spaceflight Associated Neuro-Ocular Syndrome countermeasures Swetak Pradhan, Sawan R. Dalal, Brandon M. Le, Guofu Shen, David Fleischman and Benjamin J. Frankfort 10. Pathophysiology of cerebral edema and its connection to Spaceflight Associated Neuro-Ocular Syndrome Laura Galdamez 11. Cerebral hemodynamic changes and invasive/noninvasive monitoring for Spaceflight Associated Neuro-Ocular Syndrome Eric M. Bershad, Gary Strangman and Larry A. Kramer 12. Terrestrial analogs for Spaceflight Associated Neuro-Ocular Syndrome Giovanni Taibbi and Gianmarco Vizzeri 13. Potential countermeasures for Spaceflight Associated Neuro-Ocular Julie K. Sung, Ryan Kassel, Alan Hargens and Alex S. Huang 14. Space-induced neuroocular syndrome in astronautsdthe ICP hypothesis Suraj Sulhan, David S. Baskin and Vitaliy Davidov 15. Multimodal assessment of visual function and ocular structure for monitoring Spaceflight Associated Neuro-Ocular Syndrome Nasif Zaman, Joshua Ong, Sharif Amit Kamran, Andrew G. Lee and Alireza Tavakkoli

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Author Information

Dr. Lee received his first faculty appointment in 1994 as an Instructor in the Department of Ophthalmology, Neurology, and Neurosurgery at the Baylor College of Medicine in Houston, Texas. He became an Associate Professor there in 1998 and a member of the key clinical faculty in the following year. In 2000, Dr. Lee joined the faculty at the University of Iowa in Iowa City, IA as an Associate Professor and later a full Professor in the Department of Ophthalmology, Neurology, and Neurosurgery. He serves on the editorial boards of 12 journals including the American Journal of Ophthalmology, Canadian Journal of Ophthalmology, and Eye and is the Editor in Chief of the Journal of Academic Ophthalmology. Dr. Lee is a recipient of the Honor Award, Secretariat Award, and Senior Achievement Award from the American Academy of Ophthalmology. Resident training is a particular interest of Dr. Lee. He has published several papers on teaching and competency testing methods in ophthalmology residency programs. Dr. Lee joined Houston Methodist Hospital and Research Institute in 2009 and is currently Chair of the Blanton Eye Institute at Houston Methodist Hospital and Professor of Ophthalmology, Neurology, and Neurosurgery at the Weill Cornell Medical College. Joshua Ong, MD is a resident physician with a passion for protecting astronaut health. He has conducted research on several space medicine research projects, including a project that launched into space. He has presented at the National Aeronautics and Space Administration (NASA) Human Research Program Investigators' Workshop and strives to continue his lifelong journey in ophthalmology and space medicine.

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