Overview

The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules. Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type. For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents.

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Reviews

Practicing organic chemists...rely on the series...Organic Synthesis...as a compendium of tried and tested methods for making organic compounds. The new field of solid phase organic synthesis...needs a similar reference work.... Solid Phase Organic Syntheses was created to fill this need. (Organic Process Research & Development Journal, Vol. 5, No. 6, November 2001)<br><br> This series should become as indispensable to researchers in the field of solid-phase organic synthesis as OS has been to the field of solution-phase organic synthesis. (Journal of Medicinal Chemistry, Vol. 44, No. 21, 2001)

Practicing organic chemists...rely on the series...Organic Synthesis...as a compendium of tried and tested methods for making organic compounds. The new field of solid phase organic synthesis...needs a similar reference work.... Solid Phase Organic Syntheses was created to fill this need. (Organic Process Research & Development Journal, Vol. 5, No. 6, November 2001) This series should become as indispensable to researchers in the field of solid-phase organic synthesis as OS has been to the field of solution-phase organic synthesis. (Journal of Medicinal Chemistry, Vol. 44, No. 21, 2001)

Practicing organic chemists...rely on the series...Organic Synthesis...as a compendium of tried and tested methods for making organic compounds. The new field of solid phase organic synthesis...needs a similar reference work.... Solid Phase Organic Syntheses was created to fill this need. (Organic Process Research & Development Journal, Vol. 5, No. 6, November 2001) This series should become as indispensable to researchers in the field of solid-phase organic synthesis as OS has been to the field of solution-phase organic synthesis. (Journal of Medicinal Chemistry, Vol. 44, No. 21, 2001)

Practicing organic chemists...rely on the series...Organic Synthesis...as a compendium of tried and tested methods for making organic compounds. The new field of solid phase organic synthesis...needs a similar reference work.... Solid Phase Organic Syntheses was created to fill this need. (Organic Process Research & Development Journal, Vol. 5, No. 6, November 2001)<br> <br> This series should become as indispensable to researchers in the field of solid-phase organic synthesis as OS has been to the field of solution-phase organic synthesis. (Journal of Medicinal Chemistry, Vol. 44, No. 21, 2001)

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