Overview

Soft tissue liposarcomas are rare, malignant tumors that develop from fat cells (adipocytes). They account for around 20% of soft-tissue sarcomas in adults. There are several histopathological subtypes of liposarcoma, the most common of which are well-differentiated, myxoid, pleomorphic and mixed. Well-differentiated liposarcoma is the most common, often found in the abdominal cavity, and has a relatively favorable prognosis. In contrast, myxoid and pleomorphic liposarcomas are more aggressive and have a less favorable prognosis.Symptoms usually include a painless mass of variable size, which can be detected on physical palpation or imaging examination. Diagnosis is based on histological examination after biopsy, as well as imaging techniques such as MRI or CT. The main treatment for soft-tissue liposarcoma is surgery. Radiotherapy and chemotherapy are used in more aggressive or inoperable forms. Prognosis depends on tumour size, location and histological type.

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