Overview

It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways.  Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.   

Full Product Details

Author:   Georg T. Wondrak
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 3.00cm , Length: 23.50cm
Weight:   9.066kg
ISBN:  

9783319431550

ISBN 10:   3319431552
Pages:   457
Publication Date:   31 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface. 1. The skin lipidome under environmental stress – Technological platforms, molecular pathways and  translational opportunities 2. Squalene and skin barrier function: From molecular target to biomarker of environmental exposure 3. Sunlight-induced DNA damage: molecular mechanisms and photoprotection strategies 4. Urocanic Acid and Skin Photodamage: New Light on an Old Chromophore 5. The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair 6. Nitric Oxide Derivatives and Skin Environmental Exposure to light: From Molecular Pathways to Therapeutic Opportunities 7. Melanocortin 1 receptor (MC1R) as a global regulator of cutaneous UV responses: molecular interactions and opportunities for melanoma prevention 8. The Cutaneous Melanocyte as a Target of Environmental Stressors: Molecular Mechanisms and Opportunities 9. The Role of Epidermal p38 Signaling in Solar UV Radiation-induced Inflammation: Molecular Pathways and Preventive Opportunities 10. UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention 11. TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities 12. Sirtuins and stress response in skin cancer, aging, and barrier function 13. Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention 14. Regulation of Cutaneous Stress Response Pathways by the Circadian Clock: From Molecular Pathways to Therapeutic Opportunities 15. Endocannabinoids and Skin Barrier Function: Molecular Pathways and Therapeutic Opportunities 16. The aryl hydrocarbon receptor (AhR) as an environmental stress sensor and regulator of skin barrier function: Molecular mechanisms and therapeutic opportunities 17. Biological cell protection by natural compounds, a second line of defense against solar radiation 18. The Cutaneous Microbiota as a Determinant of Skin Barrier Function:  Molecular Interactions and Therapeutic Opportunities 19. Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health 20. The Cutaneous Circadian Clock as a Determinant of Environmental Vulnerability: Molecular Pathways and Chrono-pharmacological Opportunities 21. Psychological stress as a determinant of skin barrier function: Immunological pathways and therapeutic opportunities Index

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Author Information

As an Associate Professor, Pharmacology and Toxicology, College of Pharmacy, University of Arizona and President of the American Society for Photobiology (ASP; 2016-2018), Dr. Wondrak's research examines the pathological role of oxidative and proteotoxic stress in solar photodamage and skin cancer aiming at the design of novel molecular strategies for prevention and therapeutic intervention. http://www.pharmacy.arizona.edu/directory/georg-wondrak-phd 

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