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Author:   Peter F. Surai ,  Anton Surai
Publisher:   Brill Wageningen Academic
Imprint:   Brill Wageningen Academic
Weight:   1.044kg
ISBN:  

9789086863914

ISBN 10:   9086863914
Pages:   556
Publication Date:   28 June 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Preface7 About the authors9 Table of contents11 Abbreviations17 Chapter 1 A search for ideal diets, the case of polyphenols27  Abstract27  Keywords28  1.1 Introduction28  1.2 What are ideal diets?28  1.3 What are polyphenols?34  1.4 Antioxidant activities of polyphenols35  1.5 Pro-oxidant properties of polyphenols39  1.6 Polyphenol effects in poultry and farm animals41  1.7 Polyphenols vs vitamin E46  1.8 Detrimental effects of polyphenols51  1.9 Conclusions53  References55 Chapter 2 From milk thistle to silymarin: chemical and pharmacological properties67  Abstract67  Keywords68  2.1 Introduction68  2.2 History of milk thistle/SM investigation68  2.3 Chemical composition and structure73  2.4 Pharmacokinetics75  2.5 Silymarin toxicity78  2.6 Silymarin applications79  2.7 Conclusions79  References80 Chapter 3 Antioxidant defence systems in health and diseases85  Abstract85  Keywords86  3.1 Introduction86  3.2 Free radicals and reactive oxygen and nitrogen species86  3.3 Three levels of antioxidant defence89  3.4 Antioxidant defence network92  3.5 Oxidative stress and redox biology95  3.6 Stress-response pathways95  3.7 Conclusions99  References101 Chapter 4 Antioxidant properties of silymarin105  Abstract105  Keywords105  4.1 Introduction106  4.2 Direct free radical scavenging106  4.3 Inhibition of free-radical producing enzymes by silybin107  4.4 Protective effects of silybin on mitochondria, a main source of free radical production in the cell108  4.5 Is effective silybin concentration in vitro achievable in vivo?117  4.6 Oxidability and pro-oxidant properties of silymarin118  4.7 Conclusions119  References120 Chapter 5 Silymarin and Nrf2127  Abstract127  Keywords127  5.1 Introduction128  5.2 Transcription factor Nrf2128  5.3 Pharmacological/nutritional Nrf2 activation135  5.4 Nrf2 and inflammation140  5.5 Nrf2 activation as a clinical strategy141  5.6 Silymarin and Nrf2 regulation141  5.7 Conclusions143  References144 Chapter 6 Silymarin and NF-κB151  Abstract151  Keywords152  6.1 Introduction152  6.2 Transcription factor NF-κB152  6.3 NF-κB and oxidative stress158  6.4 Nutritional modulation of NF-κB159  6.5 Silymarin and NF-κB regulation161  6.6 Nrf2 and NF-ĸB interplay in oxidative stress163  6.7 Conclusions167  References168 Chapter 7 Silymarin and vitagenes179  Abstract179  Keywords179  7.1 Introduction180  7.2 Vitagene family180  7.3 Effect of silymarin on vitagene expression182  7.4 Conclusions189  References190 Chapter 8 Antitoxic properties of silymarin199  Abstract199  Keywords200  8.1 Introduction200  8.2 Various compounds with toxic effects200  8.3 Oxidative stress-related conditions218  8.4 Conclusions225  References227 Chapter 9 Silymarin and immunity251  Abstract251  Keywords251  9.1 Introduction252  9.2 Natural immunity252  9.3 Adaptive immunity252  9.4 Silymarin and phagocyte functions262  9.5 Silymarin and dendrites264  9.6 Silymarin and mast cells265  9.7 Silymarin and lymphocyte functions267  9.8 Molecular mechanisms of silymarin immunomodulation270  9.9 RONS, redox homeostasis and immunocommunication272  9.10 Vitagene-immunity interactions and silymarin275  9.11 Conclusions278  References279 Chapter 10 Silymarin and inflammation: from understanding molecular mechanisms to practical applications287  Abstract287  Keywords288  10.1 Introduction288  10.2 Molecular mechanisms of inflammation288  10.3 Silymarin and inflammation: In vitro studies291  10.4 Silymarin and inflammation: In vivo studies296  10.5 Conclusions305  References307 Chapter 11 Silymarin and gut health319  Abstract319  Keywords319  11.1 Introduction320  11.2 Vitagenes in gut defence321  11.3 Gut redox balance and microbiota338  11.4 Protective effects of silymarin in the gut341  11.5 Conclusions345  References346 Chapter 12 Hepatoprotective properties of silymarin363  Abstract363  Keywords363  12.1 Introduction364  12.2 Silymarin and non-alcoholic fatty liver disease364  12.3 Antiviral hepatoprotective activity of silymarin375  12.4 Conclusions377  References378 Chapter 13 Neuroprotective properties of silymarin387  Abstract387  Keywords387  13.1 Introduction388  13.2 Silymarin and Alzheimer’s disease388  13.3 Silymarin and Parkinson’s disease396  13.4 Conclusions341  References402 Chapter 14 Anti-diabetic properties of silymarin409  Abstract409  Keywords409  14.1 Introduction409  14.2 Silymarin and diabetes410  14.3 Silymarin and diabetic complications417  14.4 Conclusions419  References420 Chapter 15 Protective actions of silymarin in arthritis and cardiovascular diseases427  Abstract427  Keywords428  15.1 Introduction428  15.2 Silymarin and arthritis428  15.3 Silymarin and cardiovascular diseases430  15.4 Anticancer activities of silymarin434  15.5 Conclusions435  References436 Chapter 16 Other beneficial effects of silymarin441  Abstract441  Keywords441  16.1 Introduction442  16.2 SM and amatoxin-containing mushrooms poisoning442  16.3 Silymarin in exercising and stress443  16.4 Silymarin and burn recovery445  16.5 Anti-aging effects of silymarin445  16.6 Silymarin and multidrug resistance446  16.7 Combined protective effects of silymarin and other antioxidants448  16.8 Silymarin-drug interactions449  16.9 Conclusions453  References453 Chapter 17 Silymarin in poultry and farm animal nutrition and health463  Abstract463  Keywords463  17.1 Introduction464  17.2 Silymarin in poultry464  17.3 Silymarin in farm animals469  17.4 Conclusions474  References475 Chapter 18 From hepatoprotection to general health of poultry479  Abstract479  Keywords480  18.1 Introduction480  18.2 Usage of drinking systems for vitagene-activating nutrient mixture delivery480  18.3 VitaTonic concept development483  18.4 ShellBone concept development491  18.5 The development of multi-nutrient mixture for vitagene activation and increasing stress resistance of poultry499  18.6 Effect of the vitagene-regulating anti-stress composition on rearing birds, layer and broiler breeders505  18.7 Effects of the vitagene-regulating anti-stress composition on broilers510  18.8 Vitagene activation as an important strategy in stress prevention/ alleviation516  18.9 Conclusions516  References517 Chapter 19 Looking ahead: silymarin and health535  Abstract535  Keywords535  19.1 Introduction536  19.2 Silymarin and oestrogen receptor regulation536  19.3 Silymarin and transcription factors PPARs539  19.4 Increasing silymarin availability is a way forward545  19.5 Conclusions546  References548

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