Overview

Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering.

Full Product Details

Author:   Subhas Kundu
Publisher:   Elsevier Science & Technology
Imprint:   Woodhead Publishing Ltd
Dimensions:   Width: 15.60cm , Height: 3.10cm , Length: 23.40cm
Weight:   0.821kg
ISBN:  

9780081013885

ISBN 10:   0081013884
Pages:   582
Publication Date:   30 October 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Part I: Fundamentals, processing and types of silk biomaterials Chapter 1: Introduction to silk biomaterials Abstract: 1.1 Introduction 1.2 General information about silkworms 1.3 Silk proteins 1.4 Genetics of silkworms 1.5 Diseases of silkworms 1.6 Applications of silks 1.7 Application of silk protein fibroins 1.8 Application of silk protein sericins 1.9 Conclusion 1.10 Acknowledgments Chapter 2: Applications of silk biomaterials in tissue engineering and regenerative medicine Abstract: 2.1 Introduction 2.2 Silk scaffolds in tissue engineering and regenerative medicine 2.3 Hard tissue engineering 2.4 Soft tissue engineering 2.5 Tissue engineering for application in specific organs 2.6 Conclusion and future trends 2.7 Acknowledgments Chapter 3: Processing of Bombyx mori silk for biomedical applications Abstract: 3.1 Introduction 3.2 Modulation of silk biomaterial properties 3.3 Silk fibroin materials and their use in biomedical applications 3.4 Conclusion and future trends Chapter 4: Silk nanostructures based on natural and engineered self-assembly Abstract: 4.1 Introduction 4.2 Mechanisms of self-assembly in natural and engineered systems 4.3 Assembly of natural and recombinant silk proteins 4.4 Engineering the self-assembly of silk 4.5 Silk nano-architectures and their applications 4.6 Self-assembly in conjugation with other (bio)materials 4.7 Conjugation with natural and synthetic materials 4.8 Conclusion and future trends Chapter 5: Electrospun silk sericin nanofibers for biomedical applications Abstract: 5.1 Introduction 5.2 Application of silk sericin in the biomedical field 5.3 Electrospinning 5.4 Silk sericin nanofibers from electrospinning 5.5 Molecular structure and physical properties 5.6 Silk sericin/silk fibroin blend nanofibers by electrospinning 5.7 Conclusion and future trends Chapter 6: Silk fibroin microfiber and nanofiber scaffolds for tissue engineering and regeneration Abstract: 6.1 Introduction 6.2 Silk fibroin (SF) microfibers for skin and connective tissue regeneration 6.3 Formic acid (FA)-cross-linked 3-D SF microfiber-based nonwovens 6.4 SF microfiber-based carded-needled 3-D nonwovens 6.5 Nanofibers from electrospinning and tissue engineering 6.6 Electrospun SF tubes for small calibre blood vessel regeneration Chapter 7: Silk powder for regenerative medicine Abstract: 7.1 Introduction 7.2 Silk particle production by the bottom up approach 7.3 Silk powder production by the top down approach (milling) 7.4 Characterisation of silk powder 7.5 Applications of silk particles 7.6 Conclusion Part II: Properties and behaviour of silk biomaterials Chapter 8: Biochemical and biophysical properties of native Bombyx mori silk for tissue engineering applications Abstract: 8.1 Introduction 8.2 Genetic sequence and primary structure of silk proteins 8.3 Structure and assembly of native silk fibroin 8.4 Physical and chemical properties of native silk fibroin fibers 8.5 Conclusion Chapter 9: Structure and properties of spider and silkworm silk for tissue scaffolds Abstract: 9.1 Introduction 9.2 Microstructure of silks 9.3 Mechanical properties 9.4 Relationship between structure and properties 9.5 Biomimetic approaches 9.6 Conclusion 9.7 Acknowledgments Chapter 10: Types and properties of non-mulberry silk biomaterials for tissue engineering applications Abstract: 10.1 Introduction 10.2 Classification of silkworms 10.3 Life cycle of silkworms 10.4 Types of non-mulberry silk 10.5 Structure and mechanical properties of silk 10.6 Processing of silk proteins 10.7 Different formats of silk protein as biomaterials: fibroin 10.8 Different formats of silk protein as biomaterials: sericin 10.9 Applications of non-mulberry silk protein as biomaterials in biomedicine and biotechnology 10.10 Immunological response to silk 10.11 Silk degradation 10.12 Conclusion and future trends Chapter 11: Bio-response to silk sericin Abstract: 11.1 Introduction 11.2 Biological responses to biomaterials 11.3 Aspects of tissue responses to biomaterials 11.4 Evaluation of biological responses to biomaterials 11.5 Significant issues in in vivo testing 11.6 Reports on biological responses to silk sericin 11.7 Investigation of biological responses to silk sericin 11.8 Clinical investigation of silk sericin 11.9 Conclusion 11.10 Acknowledgement Chapter 12: Biodegradation behavior of silk biomaterials Abstract: 12.1 Introduction 12.2 In vitro biodegradation behavior of silk fibroin materials 12.3 In vivo biodegradation behavior and inflammatory responses of silk fibroin materials 12.4 Biodegradation behavior of sericin 12.5 Conclusion and future trends Chapter 13: Capillary growth behavior in porous silk films Abstract: 13.1 Introduction 13.2 Growth model of capillaries 13.3 Growth process of capillaries 13.4 The model of oxygen diffusion of the capillary and capillary density 13.5 The construction of capillary systems in biomaterials 13.6 Discussion on the oxygen concentration around a capillary 13.7 Growth process of capillaries in porous silk fibroin films (PSFFs) implanted into the dermis 13.8 Forms of angiogenesis in PSFFs after implantation 13.9 Conclusion 13.10 Acknowledgment Part III: Tissue engineering, regenerative medicine and biomedical applications of silk biomaterials Chapter 14: Silk biomaterials for intervertebral disk (IVD) tissue engineering Abstract: 14.1 Introduction 14.2 Suitability of using silk as a biomaterial in tissue engineering 14.3 Key factors to be considered before IVD tissue engineering 14.4 Tissue engineering approaches to regenerate the hierarchical architecture of IVD 14.5 Conclusions Chapter 15: Silk scaffolds for dental tissue engineering Abstract: 15.1 Introduction 15.2 Clinical challenges in dentistry 15.3 From tooth development to repair 15.4 Dental tissue engineering 15.5 Silk-based biomaterial scaffolds for dental tissue engineering 15.6 Conclusion and future trends Chapter 16: Silk for cardiac tissue engineering Abstract: 16.1 Introduction 16.2 Current therapies and their limitations 16.3 Potential strategies to treat heart disease 16.4 Specific requirements for cardiac tissue engineering 16.5 Silk protein fibroin for cardiac tissue engineering 16.6 Conclusion 16.7 Acknowledgements Chapter 17: Silk for dermal tissue engineering Abstract: 17.1 Introduction 17.2 Human skin structure, wound healing and substitute assisted wound healing 17.3 Physical properties and processing options of silk fibroin 17.4 Dermal tissue engineering using silk fibroin 17.5 Silk fibroin films, membranes and coatings 17.6 Silk fibroin hydrogels 17.7 Silk fibroin porous sponges 17.8 Silk fibroin micro-/nano-fibrous scaffolds 17.9 Conclusion and future trends Chapter 18: Silk scaffolds for three-dimensional (3D) tumor modeling Abstract: 18.1 Introduction 18.2 Biological background 18.3 Three-dimensional (3D) in vitro tumor modeling: bridging theory and clinical applications 18.4 Methods of 3D in vitro tumor modeling 18.5 How silk-based tissue engineering applications can help cancer research 18.6 Future trends 18.7 Conclusion Chapter 19: Silk hydrogels for tissue engineering and dual-drug delivery Abstract: 19.1 Introduction 19.2 Gelation of silk with ethanol 19.3 Mechanical properties and molecular networks 19.4 Bound and bulk water contents in silk hydrogel 19.5 Cell viability (cytotoxicity) 19.6 Silk-based dual-drug delivery system: hydrogels containing nanoparticles 19.7 Dual-drug release behavior from silk hydrogel 19.8 Conclusion and future trends 19.9 Acknowledgment Chapter 20: Silk for pharmaceutical and cosmeceutical applications Abstract: 20.1 Introduction 20.2 Sources of silk 20.3 Properties of silk 20.4 Methods of fabrication 20.5 Types of formulations 20.6 Pharmaceutical applications of silk 20.7 Dermatological applications 20.8 Conclusion Index

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Author Information

S. C. Kundu, Ph. D. is now European Research Area Chair and Full Professor at 3Bs Research Group, I3Bs-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Tissue Engineering and Regenerative Medicine, Portugal under European Commission Programme (FoReCaST). Before joining 3Bs Research Group, he was a Full Professor and Founder Head of Department of Biotechnology of Indian Institute of Technology (IIT) Kharagpur, India. In his early career, he was Assistant Professor to Full Professor including Head of Department at Manipur University (erstwhile Jawaharlal Nehru University Centre), Imphal, Manipur. He was also a Distinguished Invited Professor at Dankook University, South Korea. He taught genetics, cell and molecular biology and recombinant DNA technology to under-graduates, post-graduates and pre-doctoral students. Dr. Kundu received his post-doctoral training at Institute of Molecular Biology, Moscow; Department of Biology, York University, Canada; Medical University, Lubeck, Germany; Department of Biology & Biochemistry, Brunel University, UK. His chief area of interest is silk biomaterials, tissue engineering and 3D cancer modelling for drug screening. He has published 180 major research articles in journals such as Chromosoma, Experimental Cell Research, Methods in Enzymology, J Biological Chemistry, Biotechnology and Bioengineering, Acta Biomaterialia, Biomedical Microdevices, Biomaterials, Progress in Polymer Science, Biotechnology Advances, Tissue Engineering A, Nanoscale, Advanced Materials, Advanced Functional Materials, and others. He is in the editorial board member of Biomaterials, Scientific Reports, Journal of Biological Engineering, and Journal of Biomedical Materials. He is a Fellow of the National Academy of Sciences, India, West Bengal Academy of Sciences, India and Alexander von Humboldt, Germany.

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