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OverviewRecent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. Full Product DetailsAuthor: J.F. Dufour (University of Bern) , Pierre-Alain Clavien , C. Trautwein , R. Graf (Allgemeines und Orthopadisches Landeskrankenhaus Stolzalpe)Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Dimensions: Width: 17.80cm , Height: 2.50cm , Length: 25.40cm Weight: 1.095kg ISBN: 9783540229346ISBN 10: 3540229345 Pages: 464 Publication Date: 05 April 2005 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsPart I Cell Types and Matrix: Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Part II Specific Signaling Pathways: IL-6/gp130/Stat3 - Vascular Endothelial Growth Factor Signaling.-. Insulin Pathway.- Nature and Function of Hepatic Tumor Necrosis Factor-a Signaling.- The Fas/FasL Signaling Pathway.- TGF-b and the Smad Pathway in Liver Fibrogenesis.- Interferon Signaling.- CD14 and Toll Receptor.- The Wnt/b-Catenin Pathway.- Notch Signaling in Liver Disease.- Extracellular ATP: Emerging Roles of Purinergic Signaling.- Calcium Signaling.- MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival.- PI3K,PTEN and Akt.- TOR Signaling and Cell Growth Control.- Peroxisome Proliferator Activated Receptors.- Transcriptional Response to cAMP in the Liver.- Heme Oxygenase System.- Nitric Oxide.- Hypoxia-Inducible Factor-1 Signaling System.- Cyclins and CDKs in Liver Diseases.- Telomeres amd Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis.- NF-kB.- Ceramide: Cell Regulation from a Lipid Perspective.- Apoptosis and Mitochondria.- Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Diseases.- Biological Clock in the Liver.- Part III Horizons: Pharmacogenomics of Cholestatic Liver Disease.- Proteomics of Signal Transduction Pathways.- Subject Index.ReviewsFrom the reviews: <p> The text extensively describes all the known intracellular pathways present in the liver and relevant to the pathophysiology of liver diseases. a ] The text has been well written and is accompanied by clear and appropriate photographs. a ] The list of references is very detailed a ] to enable the reader to approach any topic easily. a ] This is the first textbook to be directed mainly at young basic and clinical scientists, who are interested in deepening their understanding of intracellular signaling pathways involved in liver diseases. (C. Balsano, Digestive and Liver Disease, Vol. 38, 2006) <p> This book of 35 chapters is written by an international selection of scientists and is organized in three parts. a ] This book contains an enormous amount of data. a ] The target group of this book is those starting research in liver disease. For them, but also for established scientists and surgeons with a specific interest in liver physiology and pathophysiology, this book would be of great value as a reference volume. (U. Haglund, British Journal of Surgery, Vol. 93 (1), 2006) From the reviews: The text extensively describes all the known intracellular pathways present in the liver and relevant to the pathophysiology of liver diseases. a ] The text has been well written and is accompanied by clear and appropriate photographs. a ] The list of references is very detailed a ] to enable the reader to approach any topic easily. a ] This is the first textbook to be directed mainly at young basic and clinical scientists, who are interested in deepening their understanding of intracellular signaling pathways involved in liver diseases. (C. Balsano, Digestive and Liver Disease, Vol. 38, 2006) This book of 35 chapters is written by an international selection of scientists and is organized in three parts. a ] This book contains an enormous amount of data. a ] The target group of this book is those starting research in liver disease. For them, but also for established scientists and surgeons with a specific interest in liver physiology and pathophysiology, this book would be of great value as a reference volume. (U. Haglund, British Journal of Surgery, Vol. 93 (1), 2006) From the reviews: The text extensively describes all the known intracellular pathways present in the liver and relevant to the pathophysiology of liver diseases. ??? The text has been well written and is accompanied by clear and appropriate photographs. ??? The list of references is very detailed ??? to enable the reader to approach any topic easily. ??? This is the first textbook to be directed mainly at young basic and clinical scientists, who are interested in deepening their understanding of intracellular signaling pathways involved in liver diseases. (C. Balsano, Digestive and Liver Disease, Vol. 38, 2006) This book of 35 chapters is written by an international selection of scientists and is organized in three parts. ??? This book contains an enormous amount of data. ??? The target group of this book is those starting research in liver disease. For them, but also for established scientists and surgeons with a specific interest in liver physiology and pathophysiology, this book would be of great value as a reference volume. (U. Haglund, British Journal of Surgery, Vol. 93 (1), 2006) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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