Overview

These two volumes contain the proceedings of a 3 day international meeting held at the University of Cambidge and Queens' College Cambridge from 31st July to 2nd August 1985 on the Side-Effects of Anti-Inflammatory Analgesic Drugs. The first meeting was held in Verona, (Italy) in 1982 and the organisers felt that, with a number of recent developments including the withdrawal of a num­ ber of new anti-inflammatory drugs, and concern being expressed in the lay and specialist medical press and other media about the safety of these drugs, that it was appropriate to have a second such meeting. The meeting was attended by some 300 delegates and the dis­ cussion focussed most intently on the recent issues, e. g. the value of adverse drug reaction reporting of the non-steroidal anti­ inflammatory (NSAI) drugs, certain side-effects associated with particular NSAI drugs, the predictive value of animal models etc. Organising a meeting de novo without outside help would not have been possible without the immensely valuable help given en­ thusiastically by people and financial assistance given most generously by those pharmaceutical companies listed below. These financial contributions were given despite current economic dif­ ficulties and moves to restrict the proportion of profits towards educational activities.

Full Product Details

Author:   K. D. Rainsford ,  G.P Velo
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 1987
Volume:   1
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.545kg
ISBN:  

9789401097741

ISBN 10:   9401097747
Pages:   352
Publication Date:   16 April 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Table of Contents.- Section I Clinical and Epidemiological Aspects.- 1 Introduction and historical aspects of the side-effects of anti-inflammatory analgesic drugs.- 2 Epidemiology in the United Kingdom of adverse drug reactions from non-steroidal anti-inflammatory drugs.- 3 Assessment of adverse reactions to NSAIDs: Pre- and post-marketing..- 4 Incidence of serious side effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USA.- 5 Trends and patterns in adverse drug reactions to non-steroidal anti-inflammatory drugs reported in Sweden.- 6 Rare adverse reactions to non-steroidal anti-inflammatory drugs.- 7 Pyrazolone-induced agranulocytosis: an epidemiological evaluation.- 8 Potential biases influencing interpretation of data from worldwide spontaneous ADR reports.- 9 Prescription-event monitoring of five non-steroidal anti-inflammatory drugs.- 10 Side-effects of non-steroidal anti-inflammatory drugs in children with juvenile rheumatoid arthritis.- 11 Non-steroidal anti-inflammatories: outpatient audit of patient preferences and side-effects in different diseases.- 12 Non-steroidal anti-inflammatories in the elderly.- 13 Ibuprofen overdose — the first year following over-the-counter release.- Section II Drug Interactions and Drug Metabolism.- 14 Drug interactions between the anti-inflammatory drugs and with other agents.- 15 Interactions between non-steroidal anti-inflammatory drugs and angiotensin converting enzyme inhibitors in man.- 16 Responders and non-responders to NSAI drug interactions a neglected problem?.- 17 Biological implications of the metabolic chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs.- 18 A medicinal chemist’s perspective of side-effects of anti-inflammatory analgesic drugs.- 19 Genetic andenvironmental aspects of drug metabolism relevant to side-effects in arthritic disease.- 20 Disease drug interactions: utility of the conditional concept for experimental pharmacology and toxicology in the context of inflammation.- 21 Pharmacokinetic profile of ketoprofen in elderly subjects.- 22 The effects of frusemide and Dorbanex on the pharmacokinetic profile of benoxaprofen in elderly subjects.- 23 Enantioselective dispositon of a model non-steroidal anti-inflammatory drug 2-phenylpropionic acid.- Section III Gastrointestinal Tract (Clinical Aspects).- 24 Anti-inflammatory drugs and upper gastrointestinal perforation.- 25 Piroxicam and gastrointestinal ulceration.- 26 Anti-inflammatory drugs and gastrointestinal disease. Reasons for the failure of adverse reaction reporting and surveillance systems to detect a significant association.- 27 An evaluation of the frequency of anti-inflammatory and analgesic drug intake among patients with acute gastrointestinal bleeding.

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