Overview

Sickle cell disease is one of the most relevant hemoglobinopathies worldwide and continues to represent a clinical and public health challenge. This book provides a comprehensive overview of the disease, starting with the hematological basics erythrocytes, hemoglobin and classification of anemia and then delving into the epidemiology, pathophysiology, genetics, clinical picture, diagnosis and current treatment. Hemoglobin S polymerization, chronic hemolysis, systemic inflammation and vaso-occlusion, key processes that generate multisystem damage, are clearly explained. Also addressed are diagnostic advances, the importance of neonatal screening, and contemporary therapeutic options, including hydroxyurea, transfusions, hematopoietic stem cell transplantation, and emerging gene therapies. This book is a rigorous academic resource designed for students and healthcare professionals seeking an in-depth understanding of sickle cell disease and its biological and social impact.

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