Overview

Short bowel syndrome (SBS) is defined as intestinal failure following a loss of intestinal length which causes marked maldigestion and malabsorption of dietary nutrients and induces major faecal issues, loss of energy, nitrogen, and fat. Intestinal failure and SBS continue to be important clinical problems due to their high mortality and morbidity rates, as well as their devastating socio-economic effects. Although intestinal transplantation has emerged as a feasible alternative in the treatment of children with SBS in the last two decades, intestinal adaptation remains the only chance for survival in a subset of these patients. Intestinal adaptation is defined as a process of progressive recovery from intestinal failure following bowel resection. In this book, the aetiology of SBS, its pathophysiology, and the cellular and molecular mechanisms of intestinal adaptation are reviewed. The most common complications of SBS, including intestinal failure associated liver disease and sepsis, are outlined with strategies to reduce them. The potential role of tissue engineering for SBS that go beyond the ""simple"" generation of the tubular small intestine is discussed. Such knowledge will likely provide the basis for further advances in the treatment of patients with short bowel syndrome and suggest new therapeutic strategies to maintain gut integrity, eliminate the dependence on total parenteral nutrition, and avoid the need for intestinal transplantation.

Full Product Details

Author:   Igor Sukhotnik
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   0.458kg
ISBN:  

9781629485188

ISBN 10:   1629485187
Pages:   185
Publication Date:   01 December 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Short Bowel Syndrome: Definition, Incidence, Historical Overview & Etiology; Survival Outcomes of Pediatric Intestinal Failure Patients & the Cost of Comprehensive Care; Short Bowel Syndrome: Pathophysiology & Intestinal Adaptation; Mortality & Morbidity of Short Bowel Syndrome; Intestinal Failure-Associated Liver Disease; Management of Short Bowel Syndrome; Novel Agents in the Treatment of Intestinal Failure: Humoral Factors; The World Experience of the Pediatric Intestinal Failure Program: Successful Outcomes from Intestinal Rehabilitation; Bowel-Preserving Surgery for Short Bowel Syndrome; Intestine Transplantation in Children; Tissue Engineering & Regenerative Medicine Research Perspectives for Intestinal Failure; Index.

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