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Below is a condensed version of approximately 1,000 characters, preserving the core methodology, results, and implications: ---This study examines the seismic response of reinforced concrete buildings with plan irregularities using an integrated framework that combines statistical analysis and machine learning. A comprehensive dataset covering four common irregular configurations (C, L, T, and I shapes) was analyzed using five plan irregularity ratios (L/B, L/B1, B/L2, B2/B, and L1/L) and key seismic response parameters, including base shear, storey drift, roof displacement, and roof acceleration, under far-fault and near-fault ground motions. Pearson correlation analysis identified consistent associations between the L/B ratio and base shear and displacement, though with directional and configurational variability. One-way ANOVA indicated that shape or ground motion alone does not significantly govern seismic response, whereas two-way ANOVA confirmed a significant interaction effect between geometry and excitation.

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