Overview

This volume provides an up-to-date and comprehensive overview of the anatomy, physiology, and basic and applied pharmacology of CNS serotonin neurons and serotonin receptor subtypes required for understanding the role(s) of serotonin in brain function and in behavior. The book comprises 28 chapters on various aspects of CNS serotonin neurons, such as their development, plasticity and transduction mechanisms, their structural and functional components involved in synaptic transmission, their physiological properties, their role in behavior, their putative involvement in neuropsychiatric diseases, and their role as targets of drugs used in the treatment of CNS disorders.

Full Product Details

Author:   H.G. Baumgarten ,  M. Göthert
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2000
Volume:   129
Dimensions:   Width: 15.50cm , Height: 4.00cm , Length: 23.50cm
Weight:   1.205kg
ISBN:  

9783540667155

ISBN 10:   3540667156
Pages:   767
Publication Date:   20 October 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells.- 2 Anatomy of Central Serotoninergic Projection Systems.- 3 Physiology and Pharmacology of Brain Serotoninergic Neurons.- 4 Tryptophan Hydroxylase: Molecular Biology and Regulation.- 5 Molecular Analysis of Serotonin Packaging into Secretory Vesicles.- 6 Regulation of the Environment of the Interior of Serotonin-Storing Vesicles.- 7 Molecular Biology and Transductional Characteristics of 5-HT Receptors.- 8 5-Hydroxytryptamine Receptor Histochemistry: Comparison of Receptor mRNA Distribution and Radioligand Autoradiography in the Brain.- 9 The Main Features of Central 5-HT1A Receptor.- 10 Functional Neuropharmacology of Compounds Acting at 5-HT1B/D Receptors.- 11 5-HT-Moduline, an Endogenous Peptide Modulating Serotoninergic Activity via a Direct Interaction at 5-HT1B/1D Receptors.- 12 Regulation of 5-HT Release in the CNS by Presynaptic 5-HT Autoreceptors and by 5-HT Heteroreceptors.- 13 Behavioral Consequences of 5-HT1BReceptor Gene Deletion.- 14 Pharmacology of 5-HT2Receptors.- 15 Regulation of 5-HT2AReceptor at the Molecular Level.- 16 Neuropharmacology of 5-HT3Receptor Ligands.- 17 5-HT4Receptors: An Update.- 18 Molecular Biology and Potential Functional Role of 5-HT5, 5-HT6, and 5-HT7 Receptors.- 19 Electrophysiology of 5-HT Receptors.- 20 5-HT Receptors Involved in the Regulation of Hormone Secretion.- 21 Role of Serotoninergic Neurons and 5-HT Receptors in the Action of Hallucinogens.- 22 The Interaction of the Serotoninergic and Other Neuroregulatory Systems in Alcohol Dependence.- 23 Neuronal Pathophysiology of Migraine as a Basis for Acute Treatment with 5-HT Receptor Ligands.- 24 Modulation of Nociception by Descending Serotoninergic Projections.- 25 Molecular Biology of Monoamine Oxidase A and B: Their Role in the Degradation of Serotonin.- 26 Molecular Biology, Pharmacology, and Genetics of the Serotonin Transporter: Psychobiological and Clinical Implications.- 27 Animal Models of Integrated Serotoninergic Functions: Their Predictive Value for the Clinical Applicability of Drugs Interfering with Serotoninergic Transmission.- 28 Current Psychiatric Uses of Drugs Acting on the Serotonin System.

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