Overview

The seroepidemiology of transfusion- transmitted infections such as Toxoplasma gondii, cytomegalovirus (CMV), and parvovirus B19 among healthy blood donors in India underscores a significant public health concern, particularly for immunocompromised individuals, neonates, and pregnant women. Studies from various regions in India reveal that the seroprevalence of T. gondii IgG antibodies among blood donors ranges from approximately 20% to 25%, indicating past exposure, with a smaller percentage showing IgM positivity, suggesting recent infections . CMV exhibits a notably high seroprevalence among Indian blood donors, with IgG positivity rates reported between 90% and 97%, reflecting widespread prior exposure, while IgM positivity remains low, indicating fewer recent infections . Parvovirus B19 seroprevalence studies indicate that IgG antibodies are present in approximately 27% to 40% of donors, signifying previous exposure, with IgM antibodies detected in about 1.4% to 7.5% of donors, pointing to current or recent infections.

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