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Author:   Challa S. S. R. Kumar (Lousiana State University, Baton Rouge, USA)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Dimensions:   Width: 17.80cm , Height: 2.90cm , Length: 24.60cm
Weight:   1.071kg
ISBN:  

9783527321667

ISBN 10:   3527321667
Pages:   498
Publication Date:   17 February 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

PART I: Imaging and Diagnostics QUANTUM DOTS FOR CANCER IMAGING Introduction Cancer Quantum Dots: Physics and Chemistry In Vitro Screening and Detection of Cancer Biomarkers Using Microarrays Quantum Dot Cytotoxicity and Potential Safety Concerns Concluding Remarks and Future Perspectives QUANTUM DOTS FOR TARGETED TUMOR IMAGING Introducton Types of Quantum Dots (QDs) Surface Modifications of QDs for Bioapplications Methods of Delivering QDs into Tumors Recent Advances in QDs Technology Conclusion and Perspectives MULTIPLEXED BIOIMAGING USING QUANTUM DOTS Introduction The Need for Novel Multiplex Imaging Systems Quantum Dots Bioimaging Applications of Quantum Dots Translation to Clinical Biomarker Measurement Summary and Future Perspectives MULTIPLEXED DETECTION USING QUANTUM DOTS Introduction In Vitro Multiplexed Analysis Using QDs Multiplexed Imaging Using QDs Summary PART II: Therapy MEDICAL DIAGNOSTICS OF QUANTUM DOT-BASED PROTEIN MICRO- AND NANOARRAYS Introduction Protein Arrays From Microarrays to Nanoarrays: Why Nanoarrays? Functionalization of QDs for Attachment to Proteins or Other Biomolecules Fabrication of Protein Biochips QDs Probes in Clinical Applications QDs-Labeled Protein Nanoarrays Summary and Future Perspectives IMAGING AND TRACKING OF VIRUSES USING QUANTUM DOTS Introduction Quantum Dot-Biomolecule Hybrids Quantum Dots for Single Virus Tracking in Living Cells Quantum Dots for the Sensitive Detection of Virus and Infection Conclusions NANOMATERIALS FOR RADIATION THERAPY Introduction A Brief Introduction to Radiation Therapy, and its Limitations Physical Radiosensitizers Radiation Therapy in Combination with Photodynamic Therapy Using Semiconductor Nanoparticles as the Energy Mediator Nanobrachytherapy Nanoparticles as Radioprotectors Radiation Dosimeters Using Semiconductor Nanomaterials Conclusions PROSPECTS OF SEMICONDUCTOR QUANTUM DOTS FOR IMAGING AND PHOTODYNAMIC THERAPY OF CANCER Introduction Basic Principles and Challenges in PDT Advantages of Quantum Dots for PDT Synthesis of Quantum Dots Optical Properties of Quantum Dots Preparation of Biocompatible Quantum Dots Nontargeted Intracellular Delivery QDs Targeting Cancer Cells with QDs Quantum Dots for Photodynamic Therapy of Cancer Toxicity of QDs Conclusions PART III: Synthesis, Characterization, and Toxicology TYPE-I AND TYPE-II CORE-SHELL QUANTUM DOTS: SYNTHESIS AND CHARACTERIZATION Introduction Core-Shell UV-Vis Nanoparticulate Materials Characterization of Nanoheterostructures Core-Shell Infrared Nanoparticulate Materials Type I Core-Shell Infrared Structures Type II Core-Shell Infrared Structures Summary and Conclusions NANOWIRE QUANTUM DOTS Introduction Quantum Dots Growth of Quantum Dots, Nanowires and Nanowire Heterostructures Applications for Nanowires and Nanowire Quantum Dots Conclusions QUANTUM DOT-CORE SILICA GLASS-SHELL NANOMATERIALS: SYNTHESIS, CHARACTERIZATION, AND POTENTIAL BIOMEDICAL APPLICATIONS Introduction Historical Overview Incorporation of Quantum Dots in Glass Beads for Bioapplications Preparation of Cadmium-Free Quantum Dots With Water Dispersibility Summary and Future Perspective TOXICOLOGY AND BIOSAFETY EVALUATIONS OF QUANTUM DOTS Introduction The Physico-Chemical Properties of Quantum Dots Toxicity and Role of Oxidative Stress ADME and Biosafety Evaluation The Mitochondrion as a Prime Target for QD Toxicity Environmental and Ecological Concerns Concluding Comments and Future Perspectives

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Author Information

Challa Kumar is currently the Director of Nanofabrication & Nanomaterials at the Center for Advanced Microstructures and Devicees (CAMD), Baton Rouge, USA. He is also the President and CEO of Magnano Technologies, a company established to commercialize nanomaterials for applications in life sciences. His research interests are in developing novel synthetic methods, including those based on microfluidic reactors, for multifunctional nanomaterials. He has also been involved in the development of innovative therapeutic & diagnostic tools based on nanotechnology. He has eight years of industrial R&D experience working for Imperial Chemical Industries and United Breweries. He is the founding Editor-in-Chief of the Journal of Biomedical Nanotechnology, published by American Scientific Publishers and Series editor for the ten-volume book series, Nanotechnologies for the Life Sciences (NtLS), published by Wiley-VCH.

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