Overview

This is the first ever text on the intrinsic self-assembling behaviour of peptides and the implications of these properties for a broad range of applications. These include protein conformational diseases, the engineering of nanostructured biodegradable and biocompatible polymeric materials with potential applications in tissue engineering, biomedical devices, industrial fluids and personal care products. This new area of endeavour is outlined in a series of 25 articles summarising lectures presented at the first ever meeting on this topic held in Crete in July 1999. Audience: The articles address generic issues making the text readily amenable to postgraduate students, academics, and research scientists interested in new challenges at the physical sciences - life sciences interface.

Full Product Details

Author:   A. Aggeli ,  N. Boden ,  Zhang Shuguang
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2001
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.581kg
ISBN:  

9789048157402

ISBN 10:   9048157404
Pages:   364
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Exploiting Peptide Self-assembly to Engineer Novel Biopolymers: Tapes, Ribbons, Fibrils and Fibres.- Ribbon-Like Lamellar Structures from Chain-Folded Polypeptides.- Design of Self-Assembling Peptides as Catalyst Mimetics Using Synthetic Combinatorial Libraries.- Thermodynamics of Protein-Protein and Peptide Interactions.- The Mechanism of Amyloid Formation and Its Links to Human Disease and Biological Evolution.- Transgenic Plants for Large Scale Production of Peptides and Proteins.- Assembly Modulation of Channel-Forming Peptides.- Molecular Casting of Infectious Amyloids, Inorganic and Organic Replication: Nucleation, Conformational Change and Self-Assembly.- Structure and Stabilisation of Self-Assembling Peptide Filaments.- Designed Combinatorial Libraries of Novel Amyloid-Like Proteins.- Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules.- Amyloid-Like Fibrils from a Peptide-Analogue of the Central Domain of Silkmoth Chorion Proteins.- Amyloidogenesis of Islet Amyloid Polypeptide (IAPP).- Engineering Self-Assembly of Peptides by Amphiphilic 2D Motifs: ?-to-? Transitions of Peptides.- Model Signal Peptides: Probes of Molecular Interactions During Protein Secretion.- Structure, Folding and Assembly of Adenovirus Fibers.- Solving the Structure of Collagen.- Disulfide Bond Based Self-Assembly of Peptides Leading To Spheroidal Cyclic Trimers.- A New Circular Helicoid-Type Sequential Oligopeptide carrier for Assembling Multiple Antigenic Peptides.- Molecular Recognition in the Membrane: Role in the Folding of Membrane Proteins.- Novel Peptide Nucleic Acids with Improved Solubility and DNA-Binding Ability.- Chiral Lipid Tubules.- ?Tt-Mechanism in the Design of Self-Assembling Structures.- Self-assembling PeptideSystems in Biology and Biomedical Engineering.

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