Overview

This volume concentrates on the molecular mechanisms of neurotoxin action. Emphasis is on natural toxins, but some artificial chemical toxins are included. The first chapters deal with the topography of systems which tend to be targets of neurotoxins. They also deal with the protective barriers in the peripheral and central nervous system, which limit their access. After a chapter describing toxins affecting axonal transport, the selective vulnerability of adrenergic, cholinergic, dopaminergic, and glutaminergic neurons is treated on the molecular level of enzymes, transport systems and receptors. A special aspect of neurotoxicity, the production of tumours in the nervous system by neurotrophic carcinogens, is reported in a separate chapter. Tetanus and botulinum neutoroxins as well as other bacterial toxins, which are not neurotoxins sensu strictu, but are used as valuable tools by neuroscientists, and toxins affecting ion channels (Na+-, K+-, CA2+-chanells) are discussed extensively. Recent progress in molecular neurobiology is comprehensively included in the respective chapters of this volume and allows new insights into the mechanisms of selective neurotoxicity.

Full Product Details

Author:   Hans Herken ,  Ferdinand Hucho
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 102
Weight:   1.605kg
ISBN:  

9783540546542

ISBN 10:   3540546545
Pages:   905
Publication Date:   11 May 1992
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Cellular and Subcellular Targets of Neurotoxins: The Concept of Selective Vulnerability.- Protective Barriers in the Peripheral Nervous System to Neurotoxic Agents.- Protective Barriers in the Nervous System Against Neurotoxic Agents: The Blood-Brain Barrier.- Kinetic and Metabolic Disorders of Axoplasmic Transport Induced by Neurotoxic Agents.- Metabolic Disorders as Consequences of Drug-Induced Energy Deficits.- Neurotoxic Synthesis by Enzymatic Error.- Neurotropic Carcinogenesis.- Neurotoxic Phenylalkylamines and Indolealkylamines.- Toxins Affecting the Cholinergic System.- Mechanisms of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Induced Destruction of Dopaminergic Neurons.- Tetanus and Botulinum Neurotoxins.- Capsaicin: Selective Toxicity for Thin Primary Sensory Neurons.- Excitotoxins, Glutamate Receptors, and Excitotoxicity.- Convulsants and Gamma-Aminobutyric Acid Receptors.- Convulsants Acting at the Inhibitory Glycine Receptor.- Peptide Toxins Acting on the Nicotinic Acetylcholine Receptor.- Nicotinic Acetylcholine Receptors and Low Molecular Weight Toxins.- Neurotoxic Agents Interacting with the Muscarinic Acetylcholine Receptor.- Peptide Toxins that Alter Neurotransmitter Release.- Sodium Channel Specific Neurotoxins: Recent Advances in the Understanding of Their Molecular Mechanisms.- Potassium Channel Toxins.- Calcium Channel Toxins.- ADP-Ribosylation of Signal-Transducing Guanine Nucleotide Binding Proteins by Cholera and Pertussis Toxin.- Clostridium botulinum C2 Toxin and C. botulinum C3 ADP-Ribosyltransferase.

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