Overview

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects: Control of tumor cell motility Role of tumor-cell adhesion and migration in organ-selective metastasis-formation Tumor heterogeneity in relation to invasion and metastasis and its clinical implications Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response Role of apoptosis in the development, progression and therapy of cancer Role of macrophages in tumor development and metastasis Pathways of macrophage-mediated tumor progression Abnormal variation of immune response against cancer Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression A biodynamical model of human T-cell proliferative disorders Current methodologies for characterization of tumor directed immune response.

Full Product Details

Author:   N.A. Nasir ,  Hans E. Kaiser ,  Aejaz Nasir
Publisher:   Springer
Imprint:   Springer
Edition:   1st ed. Softcover of orig. ed. 2008
Volume:   11
Dimensions:   Width: 19.30cm , Height: 1.40cm , Length: 26.00cm
Weight:   0.638kg
ISBN:  

9789048177066

ISBN 10:   9048177065
Pages:   250
Publication Date:   22 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Metastasis: a current perspective.- Control of cell motility during tissue invasion.- Cell adhesion and invasion during secondary tumor formation: interactions between tumor cells and host organs.- Genes and metastasis: experimental advances and clinical implications.- The evolution of diversity within tumors and metastases.- Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response.- Apoptosis and cancer.- Macrophages in tumour development and metastasis.- Classical and alternative activation of macrophages: different pathways of macrophage-mediated tumor promotion.- Characterization of tumor-directed cellular immune responses in humans.- Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression.- Abnormal variation of the immune response as related to cancer.- A biodynamical model of human T-cell development and pathology: design, testing and validation.

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