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Author:   Gordon S. Lynch
Publisher:   Springer
Imprint:   Springer
Edition:   2011 ed.
Dimensions:   Width: 15.50cm , Height: 3.00cm , Length: 23.50cm
Weight:   0.995kg
ISBN:  

9789048197125

ISBN 10:   9048197120
Pages:   479
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

1.Overview.- 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia.- 3. Age-related remodeling of neuromuscular junctions.- 4.Motor unit remodeling during aging.- 5. Age-related decline in actomyosin structure and function.- 6. Excitation-contraction coupling in aged skeletal muscle.- 7. Mitochondrial function in aging skeletal muscle.- 8. Fibrosis and skeletal muscle aging.- 9. Nuclear apoptosis and sarcopenia.- 10. Age-related changes in the molecular regulation of skeletal muscle mass.- 11. Genetic variation and skeletal muscle traits: implications for sarcopenia.- 12. Proteomic profiling of aged skeletal muscle.- 13. Aging, exercise and muscle protein metabolism.- 14. Reactive oxygen species generation and skeletal muscle wasting – implications for sarcopenia.- 15. Exercise as a countermeasure for sarcopenia.- 16. Role of contraction-induced injury in age-related muscle wasting and weakness.- 17. Role of IGF-I signaling in age-related changes in skeletal muscle.- 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia.- 19. β-Adrenergic signaling in sarcopenia and other muscle wasting disorders.

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