Overview

This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.Contents: Structure and Evolution of AdoMet-Dependent Methyltransferases (E B Fauman et al.) The Black Sheep of the Family: AdoMet-Dependent Methyltransferases that do not Fit the Consensus Structural Fold (M M Dixon et al.) Catechol O -Methyltransferase (J Vidgren et al.) Glycine N -Methyltransferase, A Tetrameric Enzyme (F Takusagawa et al.) A Protein Carboxyl Methyltransferase that Recognizes Age-Damaged Peptides and Proteins and Participates in Their Repair (S Clarke) Protein Methyltransferases Involved in Signal Transduction (S Djordjevic et al.) tRNA Methyltransferases (W M Holmes) rRNA Methyltransferases (ErmC' and ErmAm) and Antibiotic Resistance (C Abad-Zapatero et al.) Nucleoside Methylation in Eukaryotic mRNA: HeLa mRNA (N6-Adenosine)-Methyltransferase (J A Bokar & F M Rottman) VP39 An mRNA Cap-Specific 2'- O -Methyltransferase (A E Hodel et al.) Bacterial DNA Methyltransferases (D T F Dryden) Eukaryotic DNA Methyltransferases (P M Vertino) Mechanisms of DNA Demethylation in Vertebrates (J-P Jost et al.) Readership: Students and researchers in biochemistry, enzymology, catalytic mechanisms, protein structure and enzyme evolution.

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