Overview

Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions. David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School

Full Product Details

Author:   Xander H. T. Wehrens ,  Andrew R. Marks
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2005 ed.
Volume:   254
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   1.490kg
ISBN:  

9780387231877

ISBN 10:   0387231870
Pages:   330
Publication Date:   09 November 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Evolution of the Ryanodine Receptor Gene Family.- Topology and Transmembrane Organization of Ryanodine Receptors.- Three-Dimensional Reconstruction of Ryanodine Receptors.- RYR-DHPR Relationships in Skeletal and Cardiac Muscles.- The Pore of the Ryanodine Receptor Channel.- Intra-Molecular Domain-Domain Interaction.- Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium.- Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels.- Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks.- Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes.- Stability and Instability of Ca2+ Release from the SR.- Ryanodine Receptors in Smooth Muscle.- Functions of RYR3 Homologues.- Knockout Mice Lacking RYR and Junctophilin Subtypes.- Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes.- RYR1 Modulation by Calmodulin.- Ryanodine Receptor Function in Inflammation.- Ryanoids, Receptor Affinity and RYR Channel Subconductance.- Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function.- Redox Sensing by the Ryanodine Receptors.- Ryanodine Receptor Dysfunction in the Diabetic Heart.- Molecular and Clinical Genetics of RYR1 Disorders.- Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor.- The Dantrolene Binding Site on RYR1.- Ryanodine Receptor Dysfunction in Heart Failure and Arrhythmias.- Stabilization of Ryanodine Receptor as a Novel Therapeutic Strategy Against Heart Failure.- Ryanodine Receptor Antibodies and Myasthenia Gravis.

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