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Author:   Yoram Groner ,  Yoshiaki Ito ,  Paul Liu ,  James C. Neil
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2017
Volume:   962
Dimensions:   Width: 17.80cm , Height: 3.60cm , Length: 25.40cm
Weight:   1.592kg
ISBN:  

9789811032318

ISBN 10:   9811032319
Pages:   515
Publication Date:   23 March 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

RUNX in invertebrates.- Structure and biophysics of CBFb/RUNX and its transcription products.- Covalent modification of RUNX proteins: structure affects function.- The role of Runx1 in embryonic blood cell formation.- RUNX1 structure and function in blood cell development.- Roles of Runx2 in skeletal development.- Roles of Runx genes in nervous system development.- Runx family genes in tissue stem cell dynamics.- Roles of RUNX1 enhancer in normal hematopoiesis and leukemogenesis.- RUNX1-ETO leukemia.- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders.- Mechanism of ETV6-RUNX1 leukemia.- ETV6-RUNX1+ acute lymphoblastic leukemia in identical twins.- Molecular basis and targeted inhibition of CBFb-SMMHC acute myeloid leukemia.- The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models.- RUNX1 and CBFb mutations and activities of their wild-type alleles in AML.- Roles of RUNX in B cell immortalization.- Roles of RUNX in solid tumors.- RUNX3 and p53: How two tumor suppressors cooperate against oncogenic Ras.- Runx3 and cell fate decisions in pancreas cancer.- RUNX genes in breast cancer and the mammary lineage.-  Runx3 in immunity, inflammation and cancer.- Roles of RUNX complexes in immune cell development.- CBFb and HIV infection.- Roles of RUNX in Hippo pathway signaling.- Roles of RUNX in hypoxia-induced responses and angiogenesis.- The emerging roles of RUNX transcription factors in Epithelial-Mesenchymal Transition.- Regulatory role of RUNX1 and RUNX3 in the maintenance of genomic integrity.

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