Overview

Mitogaphy is a selective autophagic degradation of mitochondria, playing a crucial role in maintaining cellular homeostasis by eliminating damaged or dysfunctional mitochondria. Relating to cancer, mitophagy influences tumorigenesis, progression, and therapeutic response in complex and contradictory ways. By regulating mitochondrial quality control, energy metabolism, and apoptotic signaling, mitophagy contributes to the delicate balance between cell survival and death. This process can support cancer cell survival under stress conditions such as hypoxia and nutrient deprivation, yet it can suppress tumor development by limiting oxidative stress and genome instability. Understanding the multifaceted roles of mitophagy in cancer regulation is essential for developing targeted therapeutic strategies and improving clinical outcomes. Roles of Mitophagy in Cancer Regulation explores how mitophagy influences cell differentiation and its central role in cellular activities. It examines how mitophagy is regulated in cancer, the removal of damaged mitochondria through autophagy, and the maintenance of proper cellular functions. Covering topics such as cellular biology, DNA, and mitochondrial science, this book is an excellent resource for engineers, medical professionals, academicians, scientists, and researchers.

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Ashok Kumar Pandurangan is an associate professor in School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India. He pursued his PhD in the prestigious University of Madras, Guindy campus, Chennai, India in the area of natural products as a therapeutic agent for colorectal cancer. Later, he was postdoctoral researcher in Center for Cancer research, Children's Hospital Oakland Research Institute, Oakland, California, USA. Further he completed two postdoctoral research programs in Department of Nutrition and Dietetics, Universiti of Putra Malaysia and Department of Pharmacology, University of Malaya, Malaysia. He is currently interested to work in the area of colitis associated cancer (CAC) in murine model. Colitis associated cancer is very common nowadays in developing countries. Ulcerative Colitis (UC) is a type of Inflammatory Bowel Disease (IBD), if untreated can be a risk of developing as colitis associated cancer. Numerous studies are underway to identify drugs that control both inflammation and cell proliferation. So, he is interested in identify some novel drugs from natural source and elucidate the molecular mechanisms involved in the process of curing colitis associated cancer. He published several articles on the effects of natural agents in these areas of interest.

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