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Author:   Naranjan S. Dhalla ,  Sajal Chakraborti
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   8
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   7.139kg
ISBN:  

9781493946341

ISBN 10:   149394634
Pages:   462
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part A: Proteases and Neural Disorders.- Role of Calpain in Immunobiology of Neurodegenerative Diseases.- Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration.- Involvement of Caspases in Neurodegenaration and Stroke.- Matrix Metalloproteinases in Ischemia-Reperfusion Injury in Brain: Antioxidants as Rescuer.- The Role of Matrix Metalloproteinases in Neurovascular Injury.- The Role of Proteases in Embryonic Neural Crest Cells.- Part B: Proteases and Cancer.-      Proteases and Cancer Development.- Matrix Metalloproteinase and its Inhibitors in Cancer Progression.- Ubiquitin-Proteosome System in the Hallmarks of Cancer.- Matrix Metalloproteinases in Cancer Metastasis: An unsolved Mystery.- A Disintegrin and Metalloprotease-12 as a New target for Cancer Treatment.- Proteases and Their Role in Drug Development with an Emphasis in Cancer.- Part C: Proteases and Cardiovascular Defects.- Role of Matrix Metalloproteinases in Atherosclerosis.- The Importance of the Urokinase-type Plasminogen Activator (uPA) and its receptor (uPAR) for the Development and Progression of Atherosclerosis.- Matrix Metalloproteinases and Hypertension.- Regulation of Proteolysis in Vascular Remodeling.- Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction.- Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart.- Matrix Metalloprotease-2 in the Development and Progression of Cardiovascular Diseases.- Role of Protease Activation in Subcellular Remodeling and Heart Failure.- Proteases as Potential Targets in Left Ventricular Remodeling After Myocardial Infarction.- MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets.- Proteases as Clinical Markers of Adverse Remodeling for Heart Failure in the Aging Population.

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Author Information

Sajal Chakraborti is a professor at the University of Kalyani, India. Naranjan S. Dhalla is a professor at St. Boniface General Hospital  and the University of Manitoba, Canada.

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