Overview

Blood coagulation is a highly conserved and spontaneous physiological response after vessel injury. It restricts the excessive blood loss from our body. It includes a plethora of plasma reactions resulting in the formation of thrombin and a series of tightly regulated intracellular reactions mediated by platelet activation. In the last century, our understanding of the mechanisms and effects of blood coagulation had made significant development. Beginning from the early clinical observations of rare patients with genetic clotting disorders, our vision has reached to the introduction of newer technologies: from blood coagulation experiments to protein chemistry, to gene targeting technologies and to cure hereditary disorders by external medicinal assistance. Recently in the last decade, several studies have suggested an important contribution of blood coagulation factors in tumor progression. Here in this thesis, I have tried to explore some unanswered questions regarding i) The activation of cancer signaling pathways by clotting factors in the tumor microenvironment and its impact on primary tumor growth. ii) Intravascular activation of blood coagulation and its impact on tumor metastasis. iii) Targeting the molecular mechanism of the inflammatory ability of cancer cells to improve the therapeutic approach against cancer progression.

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