Role of Capsaicin in Oxidative Stress and Cancer

Author:   Sanjay K. Srivastava
Publisher:   Springer
Edition:   2013 ed.
Volume:   3
ISBN:  

9789400763166


Pages:   178
Publication Date:   07 May 2013
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Role of Capsaicin in Oxidative Stress and Cancer


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Overview

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Full Product Details

Author:   Sanjay K. Srivastava
Publisher:   Springer
Imprint:   Springer
Edition:   2013 ed.
Volume:   3
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   4.426kg
ISBN:  

9789400763166


ISBN 10:   9400763166
Pages:   178
Publication Date:   07 May 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids:  pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.

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