Overview

This book discusses the fundamental principles and applications of RNA synthetic biology. The initial section of the book provides fundamental concepts, including RNA synthetic biology, the use of computational biology tools for RNA design, the SELEX (Systematic Evolution of Ligands by EXponential enrichment) method, artificial intelligence for the design and prediction of RNA circuits, RNA structure prediction and folding algorithms, non-coding RNA, and in vitro selection of functional RNA. This book also highlights the practical applications of RNA synthetic biology, offering design, construction, and testing of riboswitches, riboregulators, RNA-based biosensors, CRISPR for RNA detection, RNA editing, application in nanotechnology, RNA economics, and ethics and regulatory issues. This book is intended for researchers and students of molecular biology, genetics, synthetic biology, and RNA biology. Key Features: Presents the fundamental principles and applications of RNA synthetic biology Reviews the applications of computational tools and artificial intelligence in the design, prediction, and analysis of RNAs and RNA circuits Explores the role of RNA modifications on function and the regulatory roles of non-coding RNAs Examines CRISPR-based RNA detection and RNA-based therapeutics for genetic diseases, cancer, and infectious diseases Covers the design and utilization of riboswitches, riboregulators, RNA sensors, and RNA nanotechnology Introduces design and applications of RNA aptamers and their use as diagnostic tools, therapeutics, and molecular probes

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9781032660806

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Dr. Vijai Singh is currently serving as Professor and Head of the Department of Biosciences, School of Science and Dean (Research & Innovation) at Indrashil University, Rajpur, Mehsana, India. Prior to this, he held the position of Associate Professor in the same department at Indrashil University. He has also served as Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, and in the Department of Biotechnology at the Invertis University, Bareilly, India. Earlier of his career, Dr Singh worked as a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and at the School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He earned his Ph.D. in Biotechnology in 2009 from the ICAR-National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India. His doctoral research focused on the development of molecular and immunoassays for the diagnosis of Aeromonas hydrophila. Dr. Singh’s research interests lies in the design and construction of novel biosynthetic pathways for production of medically and industrially important biomolecules. His laboratory is also actively engaged in developing CRISPR-Cas systems for gene knock out, knock in, gene regulation and diagnostic. With over 15 years of research and teaching experience, his areas of expertise include synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has an extensive academic record, with over 110 articles, 89 book chapters, 26 books and 3 patents to his credits. Dr. Singh has received number of prestigious awards, including the Bioclues Innovation, Research and Development Award (2023) from the BIOCLUES Society, the Vice Chancellor's Best Research Award (2023) from Indrashil University, and the Agathiyar Chemical Biology Award (2023) from the Society of Chemical and Synthetic Biology. At Indrashil University, he currently serves as chairman of the Board of Study, and is a member of the Academic Council of Indrashil University. He also holds the position of the Member Secretary of the Institutional Biosafety Committee (IBSC) at the university.

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