Overview

To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

Full Product Details

Author:   Robert Landick (University of Wisconsin, USA) ,  Terence Strick (Institut Jacques Monod, France) ,  Jue Wang (University of Wisconsin-Madison, USA) ,  Michelle Wang
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Edition:   2nd edition
Volume:   Volume 19
Weight:   0.596kg
ISBN:  

9781788013659

ISBN 10:   1788013654
Pages:   294
Publication Date:   15 December 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

The Transition from Transcription Initiation to Transcription Elongation: Start Site Selection, Initial Transcription, and Promoter Escape; Molecular Basis for Transcriptional Fidelity Control by RNA Polymerase II; 1RNA Polymerase as a Torsional Motor; RNA Polymerase-associated Transcription Elongation Factors; Rho Termination Factor: One Ring to Bind Them All; Global Regulation of Transcription by Nucleotides and (p)ppGpp; Helicases and the Obstructive RNAP; Transcription/Replication Conflicts, Resolution and Coregulation; Using Single-cell RNA Measurements to Decipher the Stochastic Kinetics of Transcription; Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms

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