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OverviewTrypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases. Full Product DetailsAuthor: Albrecht BindereifPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: 2012 ed. Volume: 28 Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 0.588kg ISBN: 9783642286865ISBN 10: 3642286860 Pages: 274 Publication Date: 13 June 2012 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsRNA Polymerases and Transcription Factors of Trypanosomes.- SL RNA biogenesis in kinetoplastids: a long and winding road.- Pre-mRNA splicing in Trypanosoma brucei: factors, mechanisms, and regulation.- mRNA turnover in trypanosomes.- tRNA biogenesis and processing.- rRNA biogenesis in trypanosomes.- RNA Editing in African Trypanosomes – a User’s Guide.- The RNA Interference Pathway in Trypanosoma brucei.- Translation in trypanosomatids.- Mitochondrial translation in trypanosomatids.- RNA-Seq analysis of the transcriptome of Trypanosoma brucei.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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