Rho Family GTPases

Author:   Edward J. Manser
Publisher:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2005
Volume:   3
ISBN:  

9789048168736


Pages:   298
Publication Date:   28 October 2010
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Rho Family GTPases


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Overview

Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

Full Product Details

Author:   Edward J. Manser
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2005
Volume:   3
Dimensions:   Width: 16.00cm , Height: 1.60cm , Length: 24.00cm
Weight:   0.494kg
ISBN:  

9789048168736


ISBN 10:   9048168732
Pages:   298
Publication Date:   28 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The Rho GTPases.- Evolution of the Human Rho GTPase Family.- Structural Analysis of Rho Protein Complexes.- Activation of GTPases by Dock180 Family of Proteins.- Rho GAPs — Regulators of Rho GTPases and More.- RhoA/C and the Actin Cytoskeleton.- Cdc42 and Rac Control of the Actin Cytoskeleton.- Regulation of Cell-Cell Adhesion by Rho Family GTPases.- Rho Proteins and Vesicle Trafficking.- The Prototype Rho-Associated Kinase PAK.- Genetic Analysis of Rho Protein Function in Mice.- Rho Proteins and Microtubules.

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