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OverviewRheumatoid arthritis (RA) is a chronic inflammatory disease, which affects 1% of the world's population. Patients with RA not only have a progressive and debilitating disease and severe functional impairment, but can also experience a reduced life expectancy due to frequent involvement of the major organ systems. This new edition of Rheumatoid Arthritis charts the profound changes in research and patient management that have taken place over the last 5 years. Developments in molecular biology have dramatically increased insight into the inflammatory and destructive pathways of this complex disease. Over half a million patients have been successfully treated with biologic therapy and advances in imaging techniques have allowed increasingly early detection of disease onset. Rheumatoid factor is no longer the unchallenged gold standard autoantibody but has competition from the anti-citrulline antibodies. Environmental factors influencing both susceptibility and progression have been sought, and smoking has emerged as a powerful factor. Steady progress in genetics is finally being made and one day it may be possible to predict RA before onset of symptomatic disease. It is against this backdrop of dynamic developments that the new edition of Rheumatoid Arthritis publishes. Full Product DetailsAuthor: Gary S. Firestein (Professor of Medicine, Chief, Division of Rheumatology, Allergy and Immunology, Director, University California, San Diego Clinical Investiation Institute) , Gabriel Panayi (Professor of Rheumatology, UMDS Guy's and St Thomas's, London) , Frank Wollheim (Professor of Rheumatology, Lund University Hospital, Sweden)Publisher: Oxford University Press Imprint: Oxford University Press Edition: 2nd Revised edition Dimensions: Width: 22.70cm , Height: 3.30cm , Length: 28.40cm Weight: 1.985kg ISBN: 9780198566304ISBN 10: 0198566301 Pages: 594 Publication Date: 20 July 2006 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Out of Print Availability: Out of stock ![]() Table of ContentsPreface Section 1 Etiology 1: PK Gregersen, RM Plenge, PS Gulko: Genetics of rheumatoid arthritis 2: Graciela S Alarcon, Jaime Calvo-Alen: Epidemiology and determinants of susceptibility 3: Paavo Toivanen: Microbes in the pathogenesis of rheumatoid arthritis 4: Rikard Holmdahl: Experimental models for rheumatoid arthritis Section 2 Mechanisms of inflammation 5: Raimund Kinne, Bruno Stuhmuller, Ernesta Palombo-Kinne & Gerd R Burmetser: The role of macrophages in rheumatoid arthitis 6: David A Fox: The role of T lymphocytes in rheumatoid arthritis 7: Robert P Kimberly, Jeffrey C Edberg & W Winn Chatham: The role of neutrophils in the pathogenesis of rheumatoid arthritis 8: Ulf Muller-Ladner & Steffen Gay: The role of fibroblast-like synoviocytes in rheumatoid arthritis 9: Greg Silverman: The roles of B cells in rheumatoid arthritis 10: Peter Nigrovic & David Lees: Innate immunity and immune complexes in rheumatoid arthritis 11: Christopher Buckley, Andrew Filer & Costantino Pitzalis: Angiogenesis and cell trafficking 12: William Arend & Cem Gabay: Cytokine networks 13: Gunter Steiner & Josef S Smolen: Autoantibodies in rheumatoid arthritis 14: Thomas Pap, Renate E Gay & Steffen Gay: Mechanisms of fibroblast-mediated joint destruction 15: Bruce L Kidd: Pain mechanisms in rheumatoid arthritis 16: Georg P Chrousos & Gregory A Kaltasa: The stress system and the hypothalamic-pituitary adrenal (HPA) axis in rheumatoid arthritis Section 3 Clinical Aspects 17: Paul-Peter Tak: Examination of the synovium and synovial fluid 18: Nathan J Zvaifler: Clinical aspects of rheumatoid arthritis 19: Mikkel Ostergaard, Marcin Szkudlarek & Bo Jannik Ejbjerg: Imaging in rheumatoid arthritis 20: Marjatta Leirisalo-Repo: Susceptibility, prognosis & mortality 21: Tore Saxne, Bengt Mansson & Dick Heinegarard: Biomarkers for cartilage and bone in rheumatoid arthritis Section 4 Drug Therapy 22: Garry Graham, Richard O'Day, Lynette M March, Kieran F Scott & Kenneth M Williams: NSAIDS and analgesics 23: Johannes WJ Bijlsma, Frank Buttgereit & Johannes WG Jacobs: Systemic and intra-articular glucorticoids in rheumatoid arthritis 24: Rolf Rau: Methotrexate and Leflunomide 25: Piet LCM van Riel & Eric-Jan Kroot: Gold, antimalarials, sulfasalazine, and other DMARDS 26: Antonios O Aliprantis & Michael Weinblatt: Combination therapy with synthetic DMARDs in the treatment of rheumatoid arthritis 27: Zuhre Tutuncu & Arthur Kavanaugh: Biologics in the treatment of rheumatoid arthritis Section 5 Non-Drug Therapy 28: Ulrich Mortiz: The impact of physiotherapy 29: Ylva Lindroth: Patient Education 30: Ulla Nordenskiold: Occupation therapy and assistive products and technology 31: Tore Kristian Kvien & Liv Marit Smedstad: Psychological and social aspects 32: Wolfgang Haman: Pain management 33: Leigh F Callahan: Health economics Section 6 Surgical Therapy 34: Urban Rydholm: Large joints and feet 35: Christer Sollerman: The hand 36: ATH Casey & Alan Crockard: The cervical spine Section 7 Frontiers of Therapy 37: Louise Pollard, Gabrielle Kingsley & David Scott: Design of trials involving clinical endpoints 38: Jane Freeston & Paul Emery: Clinical trials with imaging and biomark endpoints 39: Larry W Moreland & Jeffrey Curtis: New biologics: cytokines 40: Ernest Choy: New biologics: T and B cell modulators 41: Tim E Cawston & David A Young: Inhibibition of proteolytic activity involved in cartilage breakdown 42: Di Chen & Edward Schwarz: Signal transduction in rheumatic diseases 43: Frank Luyten: Mesenchymal stem cells in arthritisReviewsThe new edition of this textbook certainly deserves a place on the shelf in each rheumatology office. Rheumatology, Vol 46, This comprehensive, new edition of Rheumatoid Arthritis has been extensively updated and extended. This is an excellent reference book which I would recommend for all rheumatology departments. British Health Professionals in Rheumatology From reviews of the previous edition: `Coverage is comprehensive, informative, and, in parts, exciting. Every medical school library and rheumatology department (at least) should hold a copy.' The Lancet `a scholarly, thoroughly academic monograph for serious students of the disease whether as scientific investigators or clinicians... [a] unique, majestic tribute to the immense effort now directed at unravelling the mysteries of this field.' Scandinavian Journal of Rheumatology From reviews of the previous edition: `Coverage is comprehensive, informative, and, in parts, exciting. Every medical school library and rheumatology department (at least) should hold a copy.' The Lancet `a scholarly, thoroughly academic monograph for serious students of the disease whether as scientific investigators or clinicians... [a] unique, majestic tribute to the immense effort now directed at unravelling the mysteries of this field.' Scandinavian Journal of Rheumatology The new edition of this textbook certainly deserves a place on the shelf in each rheumatology office. Rheumatology, Vol 46, This comprehensive, new edition of Rheumatoid Arthritis has been extensively updated and extended. This is an excellent reference book which I would recommend for all rheumatology departments. British Health Professionals in Rheumatology Author InformationTab Content 6Author Website:Countries AvailableAll regions |