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The first of two special issues on signal transduction, this work contains contributions on phosphoinositide - transmitted signal transduction. The first review presents an overview of growth control, transformation and some peculiarities of lipid metabolism. Transcription factor encoding oncogenes are described. Other contributors deal with DNA damage-induced gene expression in relation to signal transduction and growth factor signalling. Phospholipases C and D and their roles in mitogenic signal transduction are discussed. An interesting issue is the involvement of serine and threonine kinases in the propagation of the early mitogenic response. An overview of lysophosphatidatic acid and its growth factor-like characteristic is offered. Growth factors may activate a Na+/H+ exchanger and/or may influence intracellular Ca2+ level. Finally, calcium signals are reviewed.

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9783540551928

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