Overview

This book provides a comprehensive analysis of biases inherent in contemporary clinical research, challenging traditional methodologies and assumptions. Aimed at students, professionals, and science enthusiasts, the book delves into fundamental principles, research tools, and ethics. It is organized in three sections: The first section covers fundamentals including framing clinical research questions, core research tools, and clinical research ethics. The second section discusses topics relevant to clinical research, organized according to their relevance in the development of a clinical study. Chapters within this section examine the strengths and limitations of traditional and alternative methods, ethical issues, and patient-centered consequences. The third section presents four in-depth case examples, illustrating issues across diverse health conditions and treatments: gastroesophageal reflux disease, hypercholesterolemia, screening for breast cancer, and depression. This examination encourages readers to critically evaluate the methodologies and assumptions underlying clinical research, promoting a nuanced understanding of evidence production in the health sciences.

Full Product Details

Author:   Karen B. Schmaling (Washington State University) ,  Robert M. Kaplan (Stanford University)
Publisher:   Cambridge University Press
Imprint:   Cambridge University Press
Weight:   0.705kg
ISBN:  

9781009391764

ISBN 10:   1009391763
Pages:   367
Publication Date:   20 March 2025
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction; Part I. Fundamentals: 1. 'Can it work? Does it work? Is it worth it?'; 2. Core research tools; 3. Clinical research ethics; Part II. Rethinking research: 4. Asking the right questions; 5. Bias in randomized controlled trials; 6. Is bigger always better?: On sample size, statistical significance, and big data; 7. Achieving transparency; 8. Understanding and restraining study costs; 9. Implementation: getting the right interventions to market; 10. Health outcomes: a comprehensive approach; 11. Confronting the crises in peer review and academic publishing; 12. Ontologies: promoting a shared scientific mission; Part III. Case studies: 13. Case study: treating gastroesophageal disease with Omeprazole; 14. Case study: statin therapy for primary prevention of heart disease; 15. Case study: cancer screening; 16. Case study: antidepressant medications; 17. Conclusions and recommendations.

Reviews

Author Information

Karen B. Schmaling is a professor of clinical psychology at Washington State University. She has over 150 publications that have been cited over 12,000 times. Her research has been supported by the US National Institutes of Health and National Science Foundation. Robert M. Kaplan is a senior scholar at Stanford University's Clinical Excellence Research Canter. He previously served as Associate Director of the National Institutes of Health, and as Chief Science Officer for the Agency for Healthcare Research and Quality. Kaplan was elected to US National Academy of Medicine in 2005.

Tab Content 6

Author Website:  

Countries Available

All regions