Overview

There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

Full Product Details

Author:   Edwin Silverman ,  Scott Weiss ,  Steven Shapiro ,  David Lomas
Publisher:   Taylor & Francis Ltd
Imprint:   Hodder Arnold
Dimensions:   Width: 21.00cm , Height: 3.50cm , Length: 27.60cm
Weight:   1.880kg
ISBN:  

9780340814321

ISBN 10:   0340814322
Pages:   496
Publication Date:   30 September 2005
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Part 1: Key Concepts in Respiratory Genetics Overview of human genetics Phenotypes for Human Respiratory Genetics Testing for association in genetic studies Sample Collection and Genotyping for Human Respiratory Genetics Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing Bioinformatics: public databases and SNPs Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues Functional genomics: clinical functional genomics Functional genomics: expression and purification of recombinant proteins Functional genomics: functional characterization of a protein Functional genomics: biophysical analysis of proteins and protein–protein interactions Functional genomics: crystallography, nuclear magnetic resonance, and modeling Functional genomics: functional analysis of mutant proteins in cells Genomic physiology in animals Pharmacogenetics Part 2: Obstructive lung diseases Asthma genetics Chronic obstructive pulmonary disease Cystic fibrosis Part 3: Interstitial lung diseases Idiopathic pulmonary fibrosis Sarcoidosis Part 4: Miscellaneous pulmonary conditions Pulmonary hypertension Genetics of lung cancer Respiratory infections Congenital, metabolic, and neuromuscular diseases Other rare lung diseases: disorders of surfactant homeostasis Other rare lung diseases: lymphangioleiomyomatosis Other rare lung diseases: Hermansky–Pudlak Syndrome

Reviews

(An) excellent introduction to the topic of respiratory genetics for people moving into the field but the book will also be a valuable reference source for investigators who already have a working knowledge of the subject. -- I.P. Hall, Human Genetics

(An) excellent introduction to the topic of respiratory genetics for people moving into the field but the book will also be a valuable reference source for investigators who already have a working knowledge of the subject. I.P. Hall, Human Genetics

Author Information

Edwin K Silverman, Assistant Professor of Medicine, Harvard Medical School, Boston, USA Steven D Shapiro, Parker B. Francis Professor of Medicine, Harvard Medical School, Brigham & Womens Hospital, Boston, USA David A Lomas, Professor, Respiratory Medicine Unit, University of Cambridge, UK Scott T Weiss, Professor of Medicine, Harvard Medical School, Boston, USA

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