Overview

Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

Full Product Details

Author:   Maio-Kun Sun
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   1.100kg
ISBN:  

9781600219603

ISBN 10:   1600219608
Pages:   438
Publication Date:   01 March 2008
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Preface; Molecular Genetics of Alzheimer's Disease; Gene Expression Abnormalities Mark the Progression of Alzheimer's Disease; Presenilins; Taupathy in Alzheimer's Disease; Intraneuronal Alzheimer's Dementia; Lipoprotein Receptors in Alzheimer's Disease; Cholesterol and Tau Hyperphosphorylation in Alzheimer's Disease; Development in Diagnostic and Therapeutic Strategies for Alzheimer's Disease; In Vivo Visualization of Amyloid Like Structures with Pet Molecular Imaging Probes; Cathepsin-B, Antiamyloidogenesis, and Neuroprotection; Environmental Enrichment: From Mouse AD Model to AD Therapy; Fragile X Mental Retardation Gene and Dementia; Category Learning in Parkinson's Disease; Cerebrovascular Disease and Dementia; Dementia and Hypertension; Index

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