Overview

Jack H. Mydlo, MD, and a panel of leading clinicians and researchers review every aspect of the latest surgical, medical, and immunological techniques that can be used in the diagnosis and treatment of renal cancer. These broadly experienced investigators also present a practical account of their best basic research methods, including the use of reverse transcriptase PCR combined with genomic hybridization, cadherin, and metalloproteinase expression to reveal important factors in the detection, staging, aggressiveness, and treatment of this disease. Gene therapy, the generation of monoclonal antibodies, and the use of interferon alpha, GM-CSF, and IL-6 are also discussed. Comprehensive and pioneering, Renal Cancer: Methods and Protocols offers urologists, medical oncologists, laboratory investigators, and pathologists a practical collection of the major cutting-edge techniques and therapies for renal cancer today, together with a view of the highly promising future of gene therapy.

Full Product Details

Author:   Jack H. Mydlo
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2001 ed.
Volume:   53
Dimensions:   Width: 15.50cm , Height: 2.60cm , Length: 23.50cm
Weight:   1.730kg
ISBN:  

9780896038288

ISBN 10:   0896038289
Pages:   403
Publication Date:   25 January 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Renal Cell Carcinoma.- Pathology of Kidney Tumors.- In Vitro Experimental Techniques.- Telomerase Assay in Renal Cancer.- Comparative Genomic Hybridization.- Analyzing the FHIT Gene by RT-PCR, Western Blotting, and Immunohistochemistry.- Detection of Apoptosis in Renal Cell Carcinoma.- Fluorescence In Situ Hybridization (FISH) to Metaphase and Interphase Chromosomes.- Polymerase Chain Reaction Detection of DNA Sequence Deletions.- Matrix Metalloproteinases and Their Inhibitors.- Purification of Growth Factor mRNA in Renal Tissues:bFGF-2, FGF-2, TGF?, and EGFR.- Laser-Capture Microdissection.- Expression of c-met and WT-1.- Molecular Analysis of the von Hippel-Lindau Disease Gene.- Experimental Models and Methods in Antibody Targeting of Renal Cell Carcinoma.- In Vivo Experimental Techniques.- Orthotopic Model of Renal Cell Carcinoma.- Murine Animal Model.- Angiogenesis Assays.- Antiangiogenic Approaches to Renal Cell Carcinoma.- Clinical Trials and Experiments.- Interferon Alpha, GM-CSF-Activated T Cells, and IL-6 in Renal Cell Carcinoma.- Immunotherapeutic Approach to Cancer with Cutaneous DNA Vaccination.- Monoclonal Antibodies.- Treatment Strategies in Metastatic Renal Cell Carcinoma.- 23 Assessment of T-Cell Immune Dysfunction in Patients with Renal Cell Carcinoma.- Transforming Growth Factor-?1 as a Novel Marker of Response to Therapy for Renal Cell Carcinoma.- Static and Flow Cytometry.

Reviews

Virtually all potentially relevant in vitro and in vivo methodologies are addressed in this book. The sections describing the respective techniques are well written and stylistically equivalent...This book will be a useful addition to most institutional libraries. It will also be of some value to experienced investigators who already possess hands-on familiarity with a particular technique, but merely wish to adapt such methodology to renal cell cancer systems. -Doody's Health Sciences Book Review Journal ...the intros are great! The writing style is surprisingly uniform and very readable. There is plentiful reference to clinical reality and a strong emphasis on novel treatments. -ACP News ...the book is well written and the experimental protocols that were included are described in great detail. - Clinical Immunology

Virtually all potentially relevant in vitro and in vivo methodologies are addressed in this book. The sections describing the respective techniques are well written and stylistically equivalent...This book will be a useful addition to most institutional libraries. It will also be of some value to experienced investigators who already possess hands-on familiarity with a particular technique, but merely wish to adapt such methodology to renal cell cancer systems. - Doody's Health Sciences Book Review Journal ...the intros are great! The writing style is surprisingly uniform and very readable. There is plentiful reference to clinical reality and a strong emphasis on novel treatments. - ACP News

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