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Author:   Dakang Xu
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2017
Volume:   1024
Weight:   0.657kg
ISBN:  

9789811059865

ISBN 10:   9811059861
Pages:   244
Publication Date:   02 October 2017
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Activation of the innate immune receptors: guardians of the micro galaxy.- Post-translational modification control of inflammatory signaling.- Emerging roles for epigenetic programming in the control of inflammatory signaling integration in heath and disease.- Roles of HDACs in the Responses of Innate Immune Cells and as Targets in Inflammatory Diseases.- Inflammasomes in the Gut Mucosal Homeostasis.- Microbial factors in inflammatory diseases and cancers.- cGAS-STING activation in the tumor microenvironment and its role in cancer immunity.- TLR Agonists as Adjuvants for Cancer Vaccines.- Telomere damage response and low-grade inflammation.- The development and diversity of ILCs，NK cells and their relevance in health and diseases

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Author Information

Dr. Dakang Xu is Professor at Shanghai Jiao Tong University and Institute of Ageing Research, Hangzhou Normal University, China. The main focus of his research team is to used a combination of genetically modified mouse models of disease, cell signalling, bioinformatics analyses and clinical applications, to understand the mechanisms of regulation of epigenetic factors in inflammatory signalling. He has also studied how modulation of the activity ofthose key factors affects the inflammatory response and tumour progression, through the function of immune cell subsets and cytokines in cancer and inflammatory diseases. This work has led to 50 peer-reviewed publications in high impact journals, including Nature Immunology,  Immunity,  Nature Communications,  PNAS and Cancer Research. 

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