Overview

The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua­ ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.

Full Product Details

Author:   H. Fraenkel-Conrat
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1977
Volume:   9
Dimensions:   Width: 17.80cm , Height: 3.20cm , Length: 25.40cm
Weight:   1.193kg
ISBN:  

9781468427202

ISBN 10:   1468427202
Pages:   614
Publication Date:   12 December 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Genetics of Polyoma Virus and Simian Virus 40.- 1. Introduction.- 2. Restriction Enzyme Maps of the Polyoma and SV40 Genomes.- 3. The Lytic Growth Cycle.- 4. Mutants of Polyoma and SV40.- 5. Viral Functions and the Early Region of the Genome.- 6. Temperature-Dependent Properties of Transformed Cells.- 7. References.- 2 Genetics of Adenoviruses.- 1. Introduction.- 2. Adenovirus Mutants.- 3. Characteristics of the Adenovirus Genetic System.- 4. Phenotypes of Adenovirus Mutants.- 5. Functional Studies Using Adenovirus Mutants.- 6. Critique and Perspectives.- 7. Note Added in Proof.- 8. References.- 3 Genetics of Herpesviruses.- 1. Introduction.- 2. Virus Mutants.- 3. Characterization of Mutants.- 4. Recombination.- 5. Effective Genomes.- 6. Validity of Recombination Analysis.- 7. The Genes of HSV.- 8. Mixed-Morphology Plaques.- 9. Transformation.- 10. Latency.- 11. References.- 4 Genetics of Picornaviruses.- 1. Introduction.- 2. Definition of a Picornavirus.- 3. The Schizon.- 4. Classification of Picornaviruses.- 5. Genetic Methods.- 6. Interactions of Picornavirus Genomes.- 7. The Genetic Recombination Map of Picornaviruses.- 8. Relation of Genetic Map to Gene Functions.- 9. Relation of Genetic Map to Gene Products.- 10. Sites of Action of Viral Growth Inhibitors.- 11. The Strategy of the Picornavirus Genome.- 12. Conclusions.- 13. References.- 5 Genetics of Togaviruses.- 1. Review of the Structure and Replication of Group A Togaviruses.- 2. Types of Mutants.- 3. Interactions of Togavirus Mutants in Mixed Infections.- 4. Physiological Defects in Temperature-Sensitive Mutants.- 5. References.- 6 Genetics of Rhabdoviruses.- 1. Introduction: Some Relevant Biological Features of Rhabdoviruses.- 2. Coding Capacity of the Genome of Rhabdoviruses.- 3. Rhabdovirus Mutants.- 4.Absence of Recombination.- 5. Complementation.- 6. Temperature-Sensitive Mutants in the Analysis of Genome Function.- 7. Defectiveness.- 8. Phenotypic Mixing and Pseudotypes.- 9. Host-Controlled Modification.- 10. Virulence and Persistent Infection.- 11. Sigma Virus and Germinal Transmission.- 12. Future Prospects.- 13. References.- 7 Genetics of Reoviruses.- 1. Introduction: Structure and Replication of Reoviruses as They Relate to Genetics.- 2. Genetic Interactions.- 3. Gene Function.- 4. Effect on Host.- 5. References.- 8 Genetics of RNA Tumor Viruses.- 1. Introduction 341 1.1. Scope of This Chapter.- 2. Basic Properties of the Virus Genome.- 3. Nonconditional Mutants and Markers.- 4. Interactions between RNA Tumor Viruses.- 5. Conditional Mutants.- 6. Biochemical Approaches to RNA Tumor Virus Genetics.- 7. Concluding Speculations.- 8. References.- 9 Genetics and Paragenetic Phenomena of Paramyxoviruses.- 1. Introduction.- 2. Properties Relevant to Genetic Analyses.- 3. Virus Populations.- 4. Origins of Mutants and Variants.- 5. Types of Mutants and Variants.- 6. Genetic and Paragenetic Phenomena.- 7. Temperature-Sensitive Mutants.- 8. Persistent Infection.- 9. Other Directions.- 10. References.- 10 Genetics of Orthomyxoviruses.- 1. Introduction.- 2. Molecular Biology of the Genome.- 3. Virus Population.- 4. Temperature-Sensitive Mutants.- 5. Conclusion.- 6. References.

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