Overview

Regucalcin is a protein which is highly differentiated due to increased conservation of the regucalcin genes throughout evolution in vertebrates. Regucalcin plays a multifunctional role in cellular regulation, including an inhibitory role in protein kinases, protein phosphatases, NO synthase, nuclear DNA and RNA synthesis. Regucalcin suppresses an enhancement of cell proliferation and apoptotic cell death that are induced by various signalling factors. Regucalcin plays a pathophysiological role in many metabolic disorders in humans. This book introduces recent topics of regucalcin studies concerning the genomics, cell regulation and diseases associated with this protein.

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9781621002598

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Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.

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