Regression Models as a Tool in Medical Research

Author:   Werner Vach
Publisher:   Taylor & Francis Ltd
ISBN:  

9781032477510


Pages:   496
Publication Date:   21 January 2023
Format:   Paperback
Availability:   In Print   Availability explained
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Regression Models as a Tool in Medical Research


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Overview

While regression models have become standard tools in medical research, understanding how to properly apply the models and interpret the results is often challenging for beginners. Regression Models as a Tool in Medical Research presents the fundamental concepts and important aspects of regression models most commonly used in medical research, including the classical regression model for continuous outcomes, the logistic regression model for binary outcomes, and the Cox proportional hazards model for survival data. The text emphasizes adequate use, correct interpretation of results, appropriate presentation of results, and avoidance of potential pitfalls. After reviewing popular models and basic methods, the book focuses on advanced topics and techniques. It considers the comparison of regression coefficients, the selection of covariates, the modeling of nonlinear and nonadditive effects, and the analysis of clustered and longitudinal data, highlighting the impact of selection mechanisms, measurement error, and incomplete covariate data. The text then covers the use of regression models to construct risk scores and predictors. It also gives an overview of more specific regression models and their applications as well as alternatives to regression modeling. The mathematical details underlying the estimation and inference techniques are provided in the appendices.

Full Product Details

Author:   Werner Vach
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.453kg
ISBN:  

9781032477510


ISBN 10:   1032477512
Pages:   496
Publication Date:   21 January 2023
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

THE BASICS: Why Use Regression Models? An Introductory Example. The Classical Multiple Regression Model. Adjusted Effects. Inference for the Classical Multiple Regression Model. Logistic Regression. Inference for the Logistic Regression Model. Categorical Covariates. Handling Ordered Categories: A First Lesson in Regression Modeling Strategies. The Cox Proportional Hazard Model. Common Pitfalls in Using Regression Models. ADVANCED TOPICS AND TECHNIQUES: Some Useful Technicalities. Comparing Regression Coefficients. Power and Sample Size. The Selection of the Sample. The Selection of Covariates. Modeling Nonlinear Effects. Transformation of Covariates. Effect Modification and Interactions. Applying Regression Models to Clustered Data. Applying Regression Models to Longitudinal Data. The Impact of Measurement Error. The Impact of Incomplete Covariate Data. RISK SCORES AND PREDICTORS: Risk Scores. Construction of Predictors. Evaluating the Predictive Performance. Outlook: Construction of Parsimonious Predictors. MISCELLANEOUS: Alternatives to Regression Modeling. Specific Regression Models. Specific Usages of Regression Models. What Is a Good Model? Final Remarks on the Role of Prespecified Models and Model Development. MATHEMATICAL DETAILS: Mathematics behind the Classical Linear Regression Model. Mathematics behind the Logistic Regression Model. The Modern Way of Inference. Mathematics for Risk Scores and Predictors. Bibliography. Index.

Reviews

The book can be recommended as a useful overview of practical aspects of regression modeling, very suitable for medical researchers who want to apply statistical methods or do apply them already now. It is also very suitable for students of statistics and their teachers. -ISCB News, 59, June 2015 With its focus on conceptual understanding and practical applications, this book is highly recommended to medical and other health science researchers who desire to improve their understanding of regression analysis for a better understanding of medical literature, for the adequate presentation of their own regression outcomes, or for improved interpretation of their results for publications and presentations. ... Additionally, this book can serve as supplemental reading for an applied graduate level course on general regression models. -Journal of Agricultural, Biological, and Environmental Statistics The book can be a very helpful contribution especially for researchers in medical sciences when performing their statistical analyses and trying to interpret the results obtained. ... This book provides plenty of practical knowledge about these basic models and also some of their extensions that is often not easy to find from statistical textbooks or from software manuals. The basic methods are well explained and illustrated by numerous practical examples, mainly using simulated datasets. -Tapio Nummi, International Statistical Review


Author Information

Werner Vach is a professor of medical informatics and clinical epidemiology at the University of Freiburg. Dr. Vach has co-authored more than 150 publications in medical journals. His research encompasses biostatistics methodology in the areas of incomplete covariate data, prognostic studies, diagnostic studies, and agreement studies.

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