Overview
The red cell has been a focus for scientific and medical investigation since the ear liest times. A higher erythrocyte sedimentation rate was associated with diseases (usually pyrexias) before the thermometer was invented. Furthermore, ever since the early observers Swammerdam and Leeuvenhoek saw discrete corpuscles in samples of blood using the first microscopes, there has been a significant scientific interest in the structure and function of red blood cells. The later discovery that red cells were not spherical, but biconcave discs introduced a scientific puzzle which is still not completely resolved today, and identified the need for a detailed knowledge of the plasma membrane composition and structure, and its interaction with the cytoskeleton. Important concepts like the lipid bilayer, together with its more recent refinement as asymmetric in phospholipid composition led to the identification of translocases involved in actively maintaining its composition. Understanding the mechanics of red cell deformation as these biconcave discs traverse capillaries was advanced by the pioneering work of Rand and Burton in the Sixties, and progressed by Evans, Skalak and others. Based on the bilayer couple hypothesis, the shape changes that are possible for a human red cell from echinocyte to stomatocyte were described by Sheetz and Singer in the Seventies in terms of alterations in the individual halves of the bilayer. Certain clinical condi tions are associated with obvious changes in red cell morphology.
Full Product Details
Author: Ingolf Bernhardt ,
J. Clive Ellory
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition: Softcover reprint of the original 1st ed. 2003
Dimensions:
Width: 15.50cm
, Height: 3.90cm
, Length: 23.50cm
Weight: 2.370kg
ISBN: 9783642079207
ISBN 10: 3642079202
Pages: 748
Publication Date: 19 December 2010
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: In Print
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Reviews
From the reviews: ""Membrane transport is a multi-faceted topic that can be looked at from various angles: biochemical, biophysical, cell biological. ‘Red Cell Membrane Transport in Health and Disease’ features contributions … from all of these areas, rendering a rather comprehensive treatise. … Bringing together chemically and physically oriented membrane researchers, the editors have assembled an impressive and varied body of knowledge that ought to be of interest in any laboratory involved in membrane transport research … ."" (T. A. Lazar, Hämostaseologie, Issue 3, 2005)
From the reviews: Membrane transport is a multi-faceted topic that can be looked at from various angles: biochemical, biophysical, cell biological. 'Red Cell Membrane Transport in Health and Disease' features contributions ! from all of these areas, rendering a rather comprehensive treatise. ! Bringing together chemically and physically oriented membrane researchers, the editors have assembled an impressive and varied body of knowledge that ought to be of interest in any laboratory involved in membrane transport research ! . (T. A. Lazar, Hamostaseologie, Issue 3, 2005)
From the reviews: Membrane transport is a multi-faceted topic that can be looked at from various angles: biochemical, biophysical, cell biological. `Red Cell Membrane Transport in Health and Disease' features contributions ... from all of these areas, rendering a rather comprehensive treatise. ... Bringing together chemically and physically oriented membrane researchers, the editors have assembled an impressive and varied body of knowledge that ought to be of interest in any laboratory involved in membrane transport research ... . (T. A. Lazar, Hamostaseologie, Issue 3, 2005)
