Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Author:   Deric L. Wheeler ,  Yosef Yarden
Publisher:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2015
ISBN:  

9781493941193


Pages:   440
Publication Date:   10 September 2016
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease


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Author:   Deric L. Wheeler ,  Yosef Yarden
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2015
Weight:   7.742kg
ISBN:  

9781493941193


ISBN 10:   1493941194
Pages:   440
Publication Date:   10 September 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The Eukaryotic Protein Kinase Superfamily.- Evolution of Receptor Tyrosine Kinases.- RTKs in Invertebrates: Lessons in Signal Transduction.- Cell Signaling by Receptor Tyrosine Kinases.- Nuclear Signaling of Receptor Tyrosine Kinases.- Computational and Modeling Aspects of RTK Networks.- Endocytosis of Receptor Tyrosine Kinases.- Structural Features of the Ligand-Binding Extracellular Domain.- Structural Features of the Kinase Domain.- Targeting RTKs in Cancer.-  Mouse Models of Receptor Tyrosine Kinases.

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Author Information

Dr. Deric Wheeler received an M.S. in pathology from the University of Iowa and a Ph.D. in cancer biology from the University of Wisconsin. He conducted his postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, WA, and at the University of Wisconsin School of Medicine and Public Health in Madison, where he eventually transitioned to faculty as an assistant professor in the department of human oncology. Dr. Wheeler’s lab research centers on resistance to molecular targeting agents and the role of subcellular localization of receptor tyrosine kinases and their roles in oncogenesis.   Dr. Yosef Yarden received a Ph.D. in molecular biology from the Weizmann Institute of Science in Rehovot, Israel. He completed postdoctoral training at Genentech, Inc. in San Francisco and at the Massachusetts Institute of Technology in Cambridge. He returned to the Weizmann Institute of Science first as an assistant professor and then later as a full professor. His past administrative responsibilities at the Weizmann Institute include Dean of the Faculty of Biology, Vice-President for Academic Affairs, Director of the M.D. Moross Institute for Cancer Research, and Dean of the Feinberg Graduate School. Dr. Yarden’s lab research centers on the roles played by growth factors and receptor tyrosine kinases in tumor progression.

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