Overview

Receptor Purification is a unique practical two-volume guide to the purification of most receptor types including receptors for neurotransmitters polypeptide hormones steroid hormones and a variety of other ligands involved in many biological processes. Today's methods of receptor purification have evolved from years of research on the mechanisms of receptor actions where they were needed to discover receptor properties and ultimately for use in cloning. Receptor Purification provides a comprehensive source of techniques to enable the purification of cloned receptors as well as a handy reference on purification of receptors from cells and tissues in a physiological context. Designed to give investigators the best possible selection of approaches to a purification problem alternative methods are provided where applicable. In addition Receptor Purification features chapters on specific agents-such as covalent binding ligands-that will greatly simplify some purification processes. Many of the leading laboratories whose work has led to the purification of a wide variety of receptors are represented in the contributions to these two volumes. In some chapters information has been added on the applications of purified receptors while others focus on the cloning of the receptors. The purification of receptors is group-based on functional ligands. The first volume is devoted to the purification of receptors that bind neurotransmitters and a wide variety of polypeptide hormones. Volume 2 covers the steroid receptors and associated proteins such as vitamin D-3 and retinoic acid receptors. Other polypeptide receptors such as those involved in

Full Product Details

Author:   Gerald Litwack
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1990 ed.
Volume:   1
Dimensions:   Width: 17.80cm , Height: 2.80cm , Length: 25.40cm
Weight:   2.460kg
ISBN:  

9780896031678

ISBN 10:   0896031675
Pages:   501
Publication Date:   23 October 1990
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Serotonin Receptors.- Purification and Cloning of Central Serotonin Receptors.- Purification of ? -Adrenergic Receptors: Isolation of Mammalian ?,-and ?2-Subtypes.- Purification of ?, ?Subunits of Guanine Nucleotide Binding Proteins.- Purification of Opioid Binding Proteins.- µ-Opioid Receptor: Purification and Reconstitutionwith GTP-Binding Protein.- The Neurotensin Receptor from Mammalian Brain: Solubilization and Purification by Affinity Chromatography.- The Luteinizing Hormone/Human Chorionic Gonadotropin Receptor of Testis and Ovary: Purification and Characterization.- Purification of LH/hCG Receptor.- The Follicle Stimulating Hormone Receptor.- Thyrotropin Receptor:Characterization and Purification.- Thyrotropin Receptor Purification.- Prolactin Receptors: Purification, Molecular Weight, and Binding Specificity.- Ligand-and Antibody-Affinity Purification of the Epidermal Growth Factor Receptor.- Platelet-Derived Growth Factor B Type Receptor.- Colony-Stimulating Factor 1 Receptor.- Insulin-Like Growth Factor-II Receptors.- Purification of Insulin and Insulin-Like Growth Factor (IGF)-I Receptor.- Insulin Receptor Isolation Through Avidin-Biotin Technology.- Insulin Receptor Purification.- Insulin Receptor Purification.- Isolation of Fibronectin Receptors.- Fibronectin Receptor Purification Using the Complementary Hydropathy Approach.- Purification of the Human Interferon-y Receptor by Ligand Affinity.- Purification of the Cholecystokinin Receptor.

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