Overview

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process! Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors shows how to assess agonist concentration-effect curve data discusses radioligand binding assays presents new in vitro multiarray assays for G-protein-coupled receptors explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions examines the role of electrophysiology in finding new drugs and drug targets describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment outlines the rationale for using angiotensin receptor antagonists and more! Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

Full Product Details

Author:   Paul Leff
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.598kg
ISBN:  

9780367400521

ISBN 10:   0367400529
Pages:   400
Publication Date:   23 September 2019
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction, James Black Principles and Measurement of Drug-Receptor Interactions The Characterization and Classification of Receptors, Patrick P. A. Humphrey Functional Methods for Quantifying Agonists and Antagonists, Iain G. Dougall Quantification of Receptor Interactions Using Binding Methods, Sebastian Lazareno Drug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, José L. Boyer, and Robert W. Dougherty The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles Kennedy Receptor-Based Drugs in Medicine Selective Adrenergic and Glucocorticoid Treatments for Asthma, David Jack Serotonin 5-HT1B/D Receptor Agonists, Graeme R. Martin Histamine H2-Receptor Antagonists, Michael E. Parsons Angiotensin Antagonists, Mark J. Robertson Experimental and Emerging Drugs -Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr. P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. Boucher Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. Eglen NMDA Receptor Antagonists, John A. Kemp and James N. C. Kew New Trends in Drug Design Computational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma Kuipers Recombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. Fernandes Inverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier

Reviews

valuableprovide[s ] information about established drugs as well as a number of drugs set to enter the marketplace or that are undergoing the approval process. The work is certainly current and definitive, and it contains chapters written by a number of well-known authorities in industry and acdemics. -Pharmaceutical Technology, 1999 this volume is essential reading for the users of the libraries of pharmaceutical companies and university departments of pharmacology, pharmacy, and medicinal chemistry. -Journal of Medicinal Chemistry

Author Information

Leff Paul

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